Publications by authors named "Yumi Sugawara"
Background: Studies on the association between multimorbidity and mortality in large populations have mainly been conducted in European and North American populations. This study aimed to identify the association between cardiometabolic multimorbidity and all-cause and cardiovascular disease (CVD) mortality in the Asia Cohort Consortium.
Methods: In this prospective cohort study, pooled analysis was performed to evaluate the association between cardiometabolic diseases (hypertension, diabetes, ischemic heart disease, and stroke), multimorbidity, and all-cause and CVD mortality, including premature mortality, among participants from 11 Asian cohort studies.
Given the female predominance of thyroid cancer, particularly in the reproductive age range, female sex hormones have been proposed as an etiology; however, previous epidemiological studies have shown conflicting results. We conducted a pooled analysis using individual data from nine prospective cohorts in the Asia Cohort Consortium to explore the association between 10 female reproductive and hormonal factors and thyroid cancer risk. Using Cox proportional hazards models, cohort-specific hazard ratios (HR) and 95% confidence intervals (CI) were estimated and then pooled using a random-effects model.
View Article and Find Full Text PDFBackground: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.
Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium.
Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women.
Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China.
Effect of Social Support on Caregiver's Functional Disability Due to Spouse's Functional Disability.
J Am Med Dir Assoc
January 2025
Objectives: To examine the effect of social support on the risk of caregiver's functional disability due to spouse's functional disability.
Design: Longitudinal study.
Setting And Participants: In this cohort study using the Ohsaki Cohort 2006 Study data, the baseline survey was conducted from December 1, 2006, to December 15, 2006, and included 7598 older adults, including 3799 couples, ≥65 years of age.
Age at menarche by birth cohort: A pooled analysis of half a million women in Asia.
Public Health
December 2024
Article Synopsis
- * Researchers found that the average age girls start their periods is about 14 years, but it has been getting younger over the past 100 years.
- * Different countries showed different trends, with some like China having ups and downs, while others like Japan and Singapore had a steady decline in the average age.
Article Synopsis
- A study examined the impact of family history of lung cancer (FHLC) on lung cancer incidence and mortality among East Asian individuals, using data from 478,354 participants across 11 cohorts.
- The findings indicated that having a family history of lung cancer increased the risk of developing lung cancer by 45%, affecting both men and women, and regardless of whether individuals were smokers or non-smokers.
- Specific lung cancer types like adenocarcinoma and squamous cell carcinoma showed even higher associated risks, but there was no significant difference in risk based on sex, smoking status, or ethnicity.
Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia.
JAMA Netw Open
August 2024
Article Synopsis
- The study examines the relationship between body mass index (BMI) and the risks of developing colorectal cancer (CRC) and dying from it in the Asian population, highlighting rising obesity rates and CRC incidence.
- The research pooled data from 17 cohort studies spanning from 1984 to 2002, with a median follow-up of 15.2 years and included nearly 620,000 participants for CRC incidence and over 650,000 for CRC-related mortality.
- Results indicate that higher BMI significantly increases the risk of incident CRC, with greater risks seen for those classified as obese, especially for colon cancer compared to rectal cancer, and a similar pattern was noted for CRC-related deaths.
Article Synopsis
- - The study aimed to evaluate the effectiveness of combining ustekinumab with budesonide versus using ustekinumab alone in treating Crohn's disease in 19 patients.
- - Results showed no significant difference in clinical remission rates or mucosal healing between the combination therapy and ustekinumab monotherapy after 8 and 32 weeks.
- - The most common side effect observed was an exacerbation of Crohn's disease, but safety profiles were comparable for both treatment groups.
Article Synopsis
- A study was conducted using data from 968,738 adults across 20 cohort studies in Asia to investigate the link between diabetes and liver cancer incidence and mortality.
- The findings revealed that adults with diabetes had a significantly higher risk of being diagnosed with liver cancer (hazard ratio of 1.97) and dying from it (adjusted hazard ratio of 1.97) compared to those without diabetes.
- The robust results, supported by a two-stage meta-analysis, contribute valuable evidence to the understanding of liver cancer risks among diabetic populations in Asian countries.
Background: The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case-control studies. We aimed to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians in a prospective study.
Methods: We included 12 prospective cohorts with 550,508 participants in the Asia Cohort Consortium.
Background: Epidemiological studies have shown inconsistent results regarding the link between smoking and breast cancer risk, despite the biological plausibility of a positive association.
Methods: Participants were 166 611 women from nine prospective cohort studies in Japan which launched in 1984-1994 and followed for 8-22 years. Information on smoking and secondhand smoke was obtained through self-administered baseline questionnaires.
The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone-related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed lung cancer risk related to reproductive factors among 308,949 Asian women across four countries, finding inconsistent results in previous research.
- - Parous women (those who have given birth) were found to have a significantly lower risk of lung cancer incidence and mortality compared to nulliparous women, especially among smokers.
- - Higher ages at first childbirth were associated with decreased lung cancer risk, while hormone replacement therapy users showed a greater likelihood of developing non-small cell lung cancer. Future research is needed to explore these findings further.
Article Synopsis
- A large study analyzed data from 444,143 Japanese individuals to investigate the relationship between body mass index (BMI) and lung cancer risk.
- Results showed that lower BMI, specifically under 18.5, increased lung cancer risk, while being overweight or obese correlated with reduced risk.
- The findings suggest an inverse relationship between BMI and lung cancer risk in the Japanese population, with the effect being more significant in male smokers, indicating possible smoking-related confounding.
Article Synopsis
- The study investigates how different birth cohorts influence the relationship between reproductive and lifestyle factors and breast cancer risk.
- It uses pooled data from 12 cohort studies and employs Cox proportional hazard regression to analyze factors like age at menarche, menopause, parity, smoking, and alcohol consumption.
- Results indicate that parity reduces breast cancer risk in older cohorts, while lifestyle factors like smoking and alcohol show stronger associations in those born in the 1950s compared to earlier cohorts.
Article Synopsis
- Body fatness is highlighted as a potential risk factor for biliary tract cancer (BTC), with established correlations between obesity and cholelithiasis (gallstones).
- A comprehensive analysis of data from over 905,000 participants across 21 studies in Asia found that higher body mass index (BMI) correlates with increased BTC mortality, especially in females.
- The study indicates that while obesity is linked to BTC mortality in women without gallstones, the relationship is less clear in men and when gallstones are present, suggesting complex interactions between BMI, gender, and gallstone presence.
Introduction: Although lung cancer prediction models are widely used to support risk-based screening, their performance outside Western populations remains uncertain. This study aims to evaluate the performance of 11 existing risk prediction models in multiple Asian populations and to refit prediction models for Asians.
Methods: In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we assessed calibration (expected-to-observed ratio) and discrimination (area under the receiver operating characteristic curve [AUC]) for each model.
Social isolation is frequently observed among survivors of disaster. However, there is limited evidence regarding the association between social isolation and adverse health outcomes among survivors of disaster. The purpose of this study was to investigate the association between social isolation and the risk of incident functional disability (IFD) among survivors of the 2011 Great East Japan Earthquake (GEJE).
View Article and Find Full Text PDFReproductive Factors and Endometrial Cancer Risk Among Women.
JAMA Netw Open
September 2023
Importance: Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries.
Objective: To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk.
Design, Setting, And Participants: This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium.
Purpose: The objective of the present study was to examine the relationship between anxiety and sleep disorder during the COVID-19 pandemic and to evaluate whether sleep disorder is mediated by the decreased frequency of going out.
Methods: The data of a total of 1976 residents aged 18 years and over who had responded to a self-reported questionnaires at a health survey in 2020 were analyzed. The subjects were divided into four groups based on their response to the questionnaire on anxiety about the COVID-19 pandemic.
Article Synopsis
- The study investigates the relationship between sleep duration and the risk of endometrial cancer in Japanese women due to increasing global incidence of the disease.
- A total of 36,537 women participated, providing data on their sleep patterns and undergoing follow-up for endometrial cancer cases.
- The results showed no significant link between sleep duration and cancer incidence, with hazard ratios indicating minimal variation between different sleep duration categories compared to a baseline of 7-8 hours.
Low back pain (LBP) and neck pain (NP) are common health problems worldwide. LBP often coexists with NP; however, the association between these pains remains unclear. The purpose of this study was to clarify the association between LBP and NP, focusing on dose-dependent effects.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore the link between dairy consumption and the risk of developing dementia in older Japanese adults aged 65 and above, following 11,637 individuals for up to 5.7 years.
- Results indicated that moderate dairy intake could be linked to a slightly reduced risk of dementia, with milk and yogurt consumers showing a lower incidence, while daily cheese consumers had an increased risk.
- The findings suggest that low dairy or milk consumption might decrease the likelihood of developing dementia, but more research is needed to clarify these associations.