Predictive Value of Perivascular Space Network and Choroid Plexus for Levodopa Responsiveness in Parkinson's Disease.

Background And Purpose: Inter-individual variability in levodopa responsiveness complicates personalized treatment of Parkinson's disease (PD). Previous studies have suggested that magnetic resonance imaging (MRI)-based indices of the perivascular space (PVS) and choroid plexus (CP) volume may be related to levodopa responsiveness. This study integrated multiple MRI indices, including CP volume, free water (FW) fraction, PVS volume fraction (PVSVF), and diffusion tensor imaging along the PVS (DTI-ALPS), to investigate their associations with levodopa responsiveness.