Characterization of Immune-Related Genes and Immune Infiltration Features in Epilepsy by Multi-Transcriptome Data.

Background: Epilepsy encompasses a group of heterogeneous brain diseases that afflict about 1% of the world's population. Accumulating evidence shows that the immune system plays a key role in epileptogenesis. Nevertheless, the immune-related mechanisms remain not been precisely understood.

Curvilinear Effects of Extraversion on Socialization Outcomes Among Chinese College Students.

The authors examine the too-much-of-a-good-thing effect (TMGT effect) in a model showing that extraversion has a curvilinear relationship with social acceptance and depression. A study of 371 freshmen in a Chinese university showed that extraversion had a curvilinear relationship with social acceptance, such that the relationship was significantly positive from lower to moderate levels of extraversion, but the positive relationship leveled off at higher levels of extraversion. Extraversion also had a curvilinear relationship with depression, such that the relationship was significantly negative from lower to moderate levels of extraversion, but the negative relationship leveled off at higher levels of extraversion.

Efficacy and safety of haloperidol for delirium prevention in adult patients: An updated meta-analysis with trial sequential analysis of randomized controlled trials.

Study Objective: To identify the efficacy and safety of haloperidol prophylaxis in adult patients with a high risk for delirium.

Design: A meta-analysis with trial sequential analysis of randomized controlled trials.

Intervention: A comprehensive search was performed in PubMed, the ISI Web of Knowledge, the Cochrane Library, and Embase databases from inception through to March 2019.

Measuring Proton Currents of Bioinspired Materials with Metallic Contacts.

Charge transfer at the interface between the active layer and the contact is essential in any device. Transfer of electronic charges across the contact/active layer interface with metal contacts is well-understood. To this end, noble metals, such as gold or platinum, are widely used.

Electrical Probes of DNA-Binding Proteins.

A DNA electrochemistry platform has been developed to probe proteins bound to DNA electrically. Here gold electrodes are modified with thiol-modified DNA, and DNA charge transport chemistry is used to probe DNA binding and enzymatic reaction both with redox-silent and redox-active proteins. For redox-active proteins, the electrochemistry permits the determination of redox potentials in the DNA-bound form, where comparisons to DNA-free potentials can be made using graphite electrodes without DNA modification.

Proton conductivity in ampullae of Lorenzini jelly.

In 1678, Stefano Lorenzini first described a network of organs of unknown function in the torpedo ray-the ampullae of Lorenzini (AoL). An individual ampulla consists of a pore on the skin that is open to the environment, a canal containing a jelly and leading to an alveolus with a series of electrosensing cells. The role of the AoL remained a mystery for almost 300 years until research demonstrated that skates, sharks, and rays detect very weak electric fields produced by a potential prey.

A Disposable paper breathalyzer with an alcohol sensing organic electrochemical transistor.

Unlabelled: Breathalyzers estimate Blood Alcohol Content (BAC) from the concentration of ethanol in the breath. Breathalyzers are easy to use but are limited either by their high price and by environmental concerns, or by a short lifetime and the need for continuous recalibration. Here, we demonstrate a proof-of-concept disposable breathalyzer using an organic electrochemical transistor (OECT) modified with alcohol dehydrogenase (ADH) as the sensor.

Proton mediated control of biochemical reactions with bioelectronic pH modulation.

In Nature, protons (H(+)) can mediate metabolic process through enzymatic reactions. Examples include glucose oxidation with glucose dehydrogenase to regulate blood glucose level, alcohol dissolution into carboxylic acid through alcohol dehydrogenase, and voltage-regulated H(+) channels activating bioluminescence in firefly and jellyfish. Artificial devices that control H(+) currents and H(+) concentration (pH) are able to actively influence biochemical processes.

Two-terminal protonic devices with synaptic-like short-term depression and device memory.

Two-terminal protonic devices with PdHx proton conducting contacts and a Nafion channel achieve 25 ms spiking, short term depression, and low-energy memory switching.

H+-type and OH- -type biological protonic semiconductors and complementary devices.

Proton conduction is essential in biological systems. Oxidative phosphorylation in mitochondria, proton pumping in bacteriorhodopsin, and uncoupling membrane potentials by the antibiotic Gramicidin are examples. In these systems, H(+) hop along chains of hydrogen bonds between water molecules and hydrophilic residues - proton wires.

A polysaccharide bioprotonic field-effect transistor.

In nature, electrical signalling occurs with ions and protons, rather than electrons. Artificial devices that can control and monitor ionic and protonic currents are thus an ideal means for interfacing with biological systems. Here we report the first demonstration of a biopolymer protonic field-effect transistor with proton-transparent PdH(x) contacts.