Exogenous ATP-induced lipolysis and its correlation with skeletal muscle atrophy and hepatic damage in fasting mice.

Adenosine triphosphate (ATP) is a critical energy currency in living organisms, yet its extracellular transport and efficacy as an exogenous energy source remain controversial. This study explored the effects of exogenous ATP administration on energy metabolism and tissue integrity in fasting mice. C57BL/6J mice were intraperitoneally injected with ATP at doses of 25, 50, and 100 mg/kg every 12 h during a 72-h fasting period.

Identification of compounds to promote diabetic wound healing based on transcriptome signature.

Purpose: Diabetic wounds are characterized by delayed healing, and the resulting diabetic foot ulcer may lead to severe complications, including amputations and mortality. This study aimed to identify potential small molecule drug candidates that can enhance diabetic wound healing through integrating transcriptome signature and experimental validation strategies.

Method: Gene expression dataset (GSE147890) from a diabetic skin humanized mice model in the Gene Expression Omnibus database was analyzed to identify differentially expressed genes between diabetic and normal skin, as well as the wound edge at 24 h.

Performance of iCare quantitative computed tomography in bone mineral density assessment of the hip and vertebral bodies in European spine phantom.

Background: Osteoporosis is a systemic bone disease which can increase the risk of osteoporotic fractures. Dual-energy X-ray absorptiometry (DXA) is considered as the clinical standard for diagnosing osteoporosis by detecting the bone mineral density (BMD) in patients, but it has flaws in distinguishing between calcification and other degenerative diseases, thus leading to inaccurate BMD levels in subjects. Mindways quantitative computed tomography (Mindways QCT) is a classical QCT system.