Immunosenescence: signaling pathways, diseases and therapeutic targets.

Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of proinflammatory cytokines in aged immune cells. Chronic inflammation contributes to a variety of age-related diseases, such as neurodegenerative disease, cancer, infectious disease, and autoimmune diseases.

Interpretable fusion methodology of health indices with an application to industrial turbine cavitation condition monitoring.

Using health indices (HIs) to characterize machine conditions is greatly helpful to prevent machine failures and their subsequent catastrophe. Fusion and interpretation of the main contributions of HIs to machine condition monitoring are still challenging. In this paper, an interpretable fusion methodology of HIs is proposed for machine condition monitoring.