Publications by authors named "Yi-Ru Ruan"
Supramolecularly assisted chlorhexidine-bacterial membrane interaction with enhanced antibacterial activity and reduced side effects.
J Colloid Interface Sci
July 2023
Article Synopsis
- Bacterial infections are a serious public health issue, prompting the development of various antibacterial agents, though improving their effectiveness while minimizing side effects is challenging.
- A new supramolecular antibacterial agent, combining cucurbit[7]uril (CB[7]) and chlorhexidine (CHX), was created, which showed significantly higher antibacterial activity than CHX alone.
- The study demonstrated that the CB[7] complex enhances the interaction with bacterial membranes and reduces toxicity and irritation associated with CHX, suggesting a new approach to drug design using supramolecular chemistry.