Biomechanical Effect of C /C Intervertebral Reconstructive Height on Adjacent Segments in Anterior Cervical Discectomy and Fusion - A Finite Element Analysis.

Objective: To investigate the biomechanical effect of different intervertebral reconstructive heights on adjacent segments following C /C anterior cervical discectomy and fusion (ACDF) through finite element analysis.

Methods: A finite element model of intact C -C segments was developed and validated for the present study. Five additional C -C postoperative models were constructed with 100%, 125%, 150%, 175%, and 200% of the benchmark height of C /C on the basis of the intact model.

Proteomics of Uterosacral Ligament Connective Tissue from Women with and without Pelvic Organ Prolapse.

Purpose: Damage to the uterosacral ligaments is an important contributor to uterine and vaginal prolapse. The aim of this study is to identify differentially expressed proteins (DEPs) in the uterosacral ligaments of women with and without pelvic organ prolapse (POP) and analyze their relationships to cellular mechanisms involved in the pathogenesis of POP.

Experimental Design: Uterosacral ligament connective tissue from four patients with POP and four control women undergo iTRAQ analysis followed by ingenuity pathway analysis (IPA) of DEPs.