Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial.

The management of overactive bladder (OAB) in women encompasses a range of strategies, from behavioral modifications to pharmacotherapy and nerve stimulation techniques. This prospective, randomized, controlled trial evaluates the efficacy of the combination of TTNS and mirabegron in symptom improvement over three months in women diagnosed with OAB. The study was designed as a randomized controlled trial.

On-demand Doppler-offset beamforming with intelligent spatiotemporal metasurfaces.

Recently, significant efforts have been devoted to guaranteeing high-quality communication services in fast-moving scenes, such as high-speed trains. The challenges lie in the Doppler effect that shifts the frequency of the transmitted signal. To this end, the recent emergence of spatiotemporal metasurfaces offers a promising solution, which can manipulate electromagnetic waves in time and space domain while being lightweight and cost-effective.

The Effect of IL-18 on Group 2 Innate Lymphoid Cells in Allergic Rhinitis.

Background: Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation by producing interleukin-4 (IL-4), IL-5, IL-9, and IL-13. IL-18 can promote T helper 2 cell (Th2) response by inducing IL-4, and IL-13 production from mast cells and basophils. However, the regulation of IL-18 on ILC2s remained unknown.

Interleukin-33 Promotes Th2/Th17 Response in Eosinophilic and Non-Eosinophilic Nasal Polyps.

Background: Interleukin-33 (IL-33) is reported to be involved in Th2-skewed eosinophilic inflammation. A recent study also found that IL-33 exerted opposite effects on Th17 response in different diseases. However, the role of IL-33 in chronic rhinosinusitis with nasal polyps (NPs) was not explored.

Sublingual Immunotherapy Decreases Expression of Interleukin-33 in Children with Allergic Rhinitis.

Objectives: To identify the expression of IL-33 during SLIT (Sublingual immunotherapy) in AR (Allergic rhinitis) children.

Methods: Thirty children received house dust mite (HDM) allergen extract for SLIT and thirty children received placebo in this study. Serum and nasal lavage samples of cases and controls were collected at different time points during SLIT.