Publications by authors named "Yasushi Nishina"
Age-related trends in amyloid positivity in Parkinson's disease without dementia.
Aging (Albany NY)
August 2025
Amyloid-beta (Aβ) plays a pivotal role in cognitive decline in Parkinson's disease (PD). The prevalence of amyloid positivity, evaluated using the cerebrospinal fluid (CSF) of patients with PD without dementia in their sixties, is lower than that in individuals with normal cognition without PD diagnosis in the same age range. However, it is unclear whether this is also the case in patients with PD without dementia in their eighties.
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- α-synuclein seed amplification assays (α-syn SAA) show promise but may have reduced sensitivity due to variations among patients with Lewy body disease (LBD).
- In a study of 34 Parkinson's disease (PD) patients and 7 with dementia with Lewy bodies (DLB), 85.2% of those with abnormal cardiac MIBG scans tested positive for α-syn SAA, while only 14.3% of those with normal scans did.
- MIBG cardiac scintigraphy was identified as a significant factor influencing α-syn SAA positivity, indicating that while α-syn SAA can be sensitive for LBD in specific cases, its effectiveness may be diminished in patients with normal M
Associations of cerebrospinal fluid monoamine metabolites with striatal dopamine transporter binding and I-meta-iodobenzylguanidine cardiac scintigraphy in Parkinson's disease: Multivariate analyses.
Ryosuke Shimasaki
,
Masanori Kurihara
,
Keiko Hatano
,
Ryoji Goto
,
Kenichiro Taira
,
Yasushi Nishina
Parkinsonism Relat Disord
November 2024
Article Synopsis
- In Parkinson's disease patients, levels of cerebrospinal fluid metabolites homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA), which are linked to dopamine and serotonin, are found to be decreased.
- A study involving 57 drug-naïve PD patients indicated significant differences in 5-HIAA levels between those with positive vs negative cardiac MIBG imaging, suggesting a direct association.
- Additionally, a correlation was found between HVA levels and striatal dopamine transporter binding, confirming that both HVA and 5-HIAA have important roles in PD pathology and imaging outcomes.
An 81-year-old woman presented with statin-induced anti-HMGCR immune-mediated necrotizing myopathy. Treatment was successful without complications with a reduced oral steroid dosage from the current consensus for all ages and backgrounds. This case suggests the importance of early diagnosis and the possibility of steroid dosage adjustment considering the patient's age, disease severity, and comorbidities.
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- Corticobasal syndrome (CBS) involves asymmetric symptoms due to issues in the cerebral cortex and basal ganglia, making early detection of imaging abnormalities difficult.
- Previous studies found asymmetric F-THK5351 PET abnormalities in CBS patients, but their effectiveness in larger early-stage groups needed further exploration.
- In a study of 15 CBS patients, 100% exhibited asymmetric tracer uptake on imaging, with F-THK5351 PET showing high sensitivity for identifying these abnormalities compared to other imaging techniques.
Article Synopsis
- The study examines the relationship between cerebrospinal fluid (CSF) homovanillic acid (HVA) and striatal dopamine transporter (DAT) binding in patients with various neurological conditions, focusing on Parkinson's disease (PD) and progressive supranuclear palsy (PSP).
- Results indicate a significant correlation between CSF HVA levels and DAT binding, especially in patients with PD (r = 0.34) and PSP (r = 0.77), suggesting that lower DAT binding may be linked to dopamine levels in the brain.
- Findings reveal that patients with PSP had the lowest DAT binding compared to those with PD, indicating that striatal DAT reduction is more pronounced in PSP, potentially reflecting
Article Synopsis
- CSF p-tau181 is a key biomarker for Alzheimer's disease (AD) and the study aimed to see if it changes in patients with Neuronal Intranuclear Inclusion Disease (NIID), a neurodegenerative disorder.
- The research compared CSF biomarker levels, including p-tau181, across 12 NIID patients, 120 confirmed AD patients, and various other neurocognitive disorder patients.
- Results showed significantly elevated CSF p-tau181 levels in NIID patients compared to others, indicating that NIID might share some biochemical features with AD despite the differences in other biomarkers like Aβ42.
[A case of hyperammonemia caused by urinary tract infection due to urease-producing bacteria in dementia with Lewy bodies].
Seiji Hashimoto
,
Yoshiaki Tamura
,
Remi Kodera
,
Aya Tachibana
,
Koichi Toyoshima
,
Yasushi Nishina
Nihon Ronen Igakkai Zasshi
May 2021
Article Synopsis
- An 87-year-old woman with dementia with Lewy bodies experienced difficulty walking and was hospitalized for a urinary tract infection (UTI).
- During her stay, she developed delirium and was treated with haloperidol, leading to altered consciousness and a subsequent diagnosis of hyperammonaemia due to urease-producing bacteria in the urine.
- After inserting a urethral catheter, her ammonia levels decreased, and her consciousness improved, highlighting the importance of considering hyperammonaemia in dementia patients, especially those on bladder function medications that may cause retention.
Article Synopsis
- DLB and AD are the most common types of dementia, and patients with both conditions have a faster cognitive decline and higher mortality rates.
- Researchers studied cerebrospinal fluid (CSF) samples to find reliable biomarkers that could help distinguish between DLB, AD, and cases where they coexist.
- Findings showed that levels of certain chemicals (HVA and 5-HIAA) in CSF were significantly lower in advanced Lewy body disorders and could be used, along with other brain proteins, to accurately differentiate between the types of dementia.
Immunolocalization of caveolin-1 and caveolin-3 in monkey skeletal, cardiac and uterine smooth muscles.
Cell Struct Funct
October 2002
Caveolin, a 20-24 kDa integral membrane protein, is a principal component of caveolar domains. Caveolin-1 is expressed predominantly in endothelial cells, fibroblasts, and adipocytes, while the expression of caveolin-3 is confined to muscle cells. However, their localization in various muscles has not been well documented.
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