Involvement of local orphanin FQ in the development of analgesic tolerance induced by morphine microinjections into the dorsal raphe nucleus of rats.

It is well known that dorsal raphe nucleus (DRN) is one of the key structures for the development of opioid analgesia and tolerance. An increased activity of 'antiopioids' like orphanin-FQ (OFQ) has been proposed as a possible mechanism for opioid tolerance. The present study evaluates the role of DRN-located OFQ in the opioid analgesic tolerance induced by repeated microinjections of morphine (MOR) into DRN.

[Comparative study on the clinical appearances between acute and chronic anterior disc displacement without reduction].

Objective: To compare the clinical appearances of TMD patients between acute and chronic anterior disc displacement without reduction.

Methods: Successive one hundred TMD patients with fully recorded documents diagnosed as anterior disc displacement without reduction (ADDw/oR) were included, 45 acute and 55 chronic ADDw/oR patients. Clinical appearances including signs and symptoms, maximal mouth opening, Fricton's craniomandibular index, condylar bone changes on radiograms, findings on arthrograms and MRI were compared.

[Epidemic survey on TCM syndrome typing and preliminary discussion on TCM etiology and pathogenesis of fatty liver].

Objective: To investigate the common TCM syndrome types of fatty liver by way of epidemic questionnaire, their occurrence ratio, and the correlation between various syndrome types and objective indexes.

Methods: A total of national wide 503 subjects with fatty liver were enrolled, the TCM syndromes, body mass index (BMI), abdominal perimeter/hip circumference, liver function, blood lipids, B ultrasonic examination and CT in them were observed and recorded.

Results: In the 46 symptoms investigated in total, the first ten symptoms in order of appearing rate were lassitude, obese, oral dryness, vertigo, hypochondriac distending pain, soreness and pain in loin, spiritlessness, oral bitterness, aching and weakness in knee and abdominal distention.

[Expression of HSP70 and P53 in malignant tumor tissues and its relationship to heat syndrome of TCM].

Objective: To investigate the expression of HSP70 and P53 in malignant tumor tissues of patients with TCM Heat-Syndrome (HS) or with non-Heat-Syndrome (NHS).

Methods: S-P immunohistochemical method was used to detect the gene expression, and ELISA and RT-PCR were adopted to determine the content of HSP70 and P53 mRNA expression in different malignant tumor tissues.

Results: (1) Positive ratio of HSP70 and P53 in the colorectal cancer of HS was significantly higher than that in colorectal cancer of NHS respectively, and the total positive ratio of the two genes in all tumors of HS was higher than those of NHS (P<0.

[A study on relationship between the contour of articular eminence and traces of the condylar kinematic center and its application in TMD patients].

Objective: To investigate the relationship between the contour of articular eminence and traces of the condylar kinematic center during jaw opening movement in healthy subjects, and compare trace characteristics of condylar kinematic center and MRI findings in TMD patients.

Methods: In 10 healthy subjects, jaw-opening motion was recorded. The kinematic center and terminal hinge axis point of the condyle were used as trace reference points.

[Temporomandibular joint disc displacement: diagnosis by arthrography with dental volumetric computerized tomography].

Objective: Temporomandibular joint sideways and rotational disc displacement was assessed by arthrography with dental volumetric computerized tomography.

Methods: The study was conducted retrospectively on 119 joints of 109 patients (87 females, 22 males, mean age 31.1 years), who had undergone arthrography with dental volumetric CT in the sagittal and coronal planes.

Study on the use of temporomandibular joint dysfunction index in temporomandibular disorders.

Objective: To study the methodological techniques in measuring the severity of temporomandibulr disorders (TMD) and in evaluating the effectiveness of therapies in clinic.

Methods: Both Fricton's Craniomandibular Index (CMI) and Helkimo's Clinical Dysfunction Index were calculated from 60 TMD patients. Inter-rater reliability was tested to assess the consistency in use between different examiners.

Color Doppler sonography of the facial artery in the anterior face.

Objectives: The purpose of this study was to clarify the Doppler sonographic features of the facial artery in the anterior face in healthy volunteers and to investigate those of related hemangiomas.

Study Design: Forty-six volunteers and 3 patients with hemangiomas were examined with Doppler sonography. The detection rates of the facial artery in the anterior face were determined.