Publications by authors named "Yanghaopeng Long"
Article Synopsis
- - The study compares two Omicron sublineages (BA.2.75 and BA.5.2) with the Delta variant to understand their effects on infection and immune response using a mouse model engineered to study human diseases.
- - Findings revealed that while Delta caused more severe lung damage, Omicron variants led to different immune responses, with BA.5.2 showing strong immune suppression and greater neurodegeneration compared to BA.2.75.
- - The differences in replication and pathogenicity among the variants are linked to how their Spike proteins interact with host cells, suggesting Omicron variants may have unique infectious characteristics that could impact neurological health.
Characteristics of replication and pathogenicity of SARS-CoV-2 Alpha and Delta isolates.
Virol Sin
December 2022
The continuously arising of SARS-CoV-2 variants has been posting a great threat to public health safety globally, from B.1.17 (Alpha), B.
View Article and Find Full Text PDFThe COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. The main protease (M) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing M inhibitors derived from either boceprevir or telaprevir, both of which are approved antivirals.
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