Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats.

Objective: This study aims to investigate the therapeutic efficacy and migration of human neural stem cell (hNSC) therapy in a rat model of moderate to severe Hypoxic-ischemic encephalopathy (HIE).

Methods: hNSCs were transplanted into the brain ventricle of HIE-induced rats. The levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), immunohistochemistry of M1 and M2 cells counts, as well as the apoptosis of hNSCs were conducted after 10 days transplantation.