Safety and 1-Year Outcomes After Transplanting Hearts From SARS-CoV-2 Positive Donors: Insights From an International Analysis.

Background: Uncertainties persist regarding the utilization of hearts from SARS-CoV-2-positive donors for heart transplant (HT). This international study analyzed such HTs within the United States (US) and Germany, focusing on 1-year outcomes and granular safety data.

Methods: Data was obtained from the United Network for Organ Sharing (UNOS) registry (03/2021-08/2022) and collaborating with the German Organ Procurement Organisation (DSO; 03/2022-02/2023).

Hemodynamic predictors of rupture in abdominal aortic aneurysms: a case series using computational fluid dynamics.

Background: Abdominal aortic aneurysm (AAA) rupture is a life-threatening event traditionally predicted by aneurysm diameter. However, many clinical observations have revealed that rupture can occur even in small aneurysms, suggesting the influence of additional biomechanical factors such as hemodynamics. The aim of this case series was to perform computational fluid dynamics (CFD) analyses based on CT scans of patients with confirmed abdominal aortic aneurysm rupture and to evaluate correlations between rupture sites and hemodynamic factors derived from simulations.

Simultaneous heart-kidney transplantation outcomes in Asian populations in the United States: A united network for organ sharing database study.

Purpose: Simultaneous heart-kidney transplantation (HKTx) remains underutilized in regions outside the United States and Europe. Assessing the clinical outcomes of HKTx in Asian recipients is crucial for promoting its adoption in Asia. This retrospective study aimed to compare the survival outcomes of HKTx between Asian and non-Hispanic White (NHW) recipients with similar baseline characteristics.

The acceptability, safety, and performance of primary cervical screening through self-collected vaginal samples in an urban teaching hospital antenatal clinic setting.

This study evaluated the feasibility, safety, and acceptability of self-collected vaginal samples for human papillomavirus (HPV) testing among pregnant women in an urban teaching hospital in Malaysia. This cross-sectional study recruited pregnant women aged 30 years and above who attended antenatal care at the University of Malaya Medical Centre. Participants self-collected vaginal samples using FLOQSwabs and completed pre- and post-sampling questionnaires assessing acceptability.

Tumor-derived EBI3 promotes CD8+ T cell exhaustion via STAT4-IL-10/CCL5 in gastric cancer.

Combination chemotherapy and immunotherapy are effective against advanced gastric cancer (GC). However, T cell exhaustion in the tumor microenvironment may decrease the immune response and compromise the effectiveness of immunotherapy. Herein, we report the potential role of EBI3 in promoting T cell exhaustion and its mechanism in GC, showing high expression of EBI3 in GC.