Optimization of Laser Cladding Process Parameters and Analysis of Organizational Properties of Mixer Liners.

Aiming to address the wear and replacement inconvenience of concrete mixer liners, this study utilizes a laser cladding system to clad Fe60 alloy powder on the liner. It investigates the influence of different process parameters on the forming quality of the Fe60 alloy powder cladding layer. The optimal process parameters were obtained by weighted comprehensive evaluation, and single-layer multi-pass cladding experiments were carried out under the optimal process parameters to investigate the effects of a 30%, 40%, and 50% lap rate on the surface flatness and forming quality of the cladding layer.

Analyses and Research on a Model for Effective Thermal Conductivity of Laser-Clad Composite Materials.

Composite materials prepared via laser cladding technology are widely used in die production and other fields. When a composite material is used for heat dissipation and heat transfer, thermal conductivity becomes an important parameter. However, obtaining effective thermal conductivity of composite materials prepared via laser cladding under different parameters requires a large number of samples and experiments.

Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models.

With 296 million chronically infected individuals worldwide, hepatitis B virus (HBV) causes a major health burden. The major challenge to cure HBV infection lies in the fact that the source of persistence infection, viral episomal covalently closed circular DNA (cccDNA), could not be targeted. In addition, HBV DNA integration, although normally results in replication-incompetent transcripts, considered as oncogenic.

Polydatin alleviates severe traumatic brain injury induced acute lung injury by inhibiting S100B mediated NETs formation.

Severe traumatic brain injury (sTBI)-induced acute lung injury (sTBI-ALI) is regarded as the most common complication of sTBI that is an independent predictor of poor outcomes in patients with sTBI and strongly increases sTBI mortality. Polydatin (PD) has been shown to have a potential therapeutic effect on sTBI-induced neurons injury and sepsis-induced acute lung injury (ALI), therefore, it is reasonable to believe that PD has a protective effect on sTBI-ALI. Here, to clarify the PD protective effect following sTBI-ALI, a rat brain injury model of lateral fluid percussion was established to mimic sTBI.