Publications by authors named "Xue-bin Fu"
A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice.
Acta Pharmacol Sin
December 2012
Article Synopsis
- The study investigates the safety and toxicity of non-radioactive (127)I-Hyp in normal mice to evaluate its potential for clinical use as a radio-derivative in therapies for ischemic heart diseases and cancers.
- The research involved administering varying doses of (127)I-Hyp, assessing clinical symptoms, blood chemistry, and histopathological outcomes.
- Results showed that up to 10 mg/kg was well tolerated without significant adverse effects, with an estimated LD(50) of 20.26 mg/kg, indicating a robust safety margin for future applications of iodinated Hypericin.