Fixed-Time Synchronization of Coupled Oscillator Networks with a Pacemaker.

This paper investigates the fixed-time synchronization problem of a Kuramoto-oscillator network in the presence of a pacemaker. Based on the framework of the cyber-physical system (CPS), fixed-time synchronization criteria of such network are presented respectively for identical and non-identical oscillators. In virtue of Lyapunov stability analyses, sufficient conditions are deduced for achieving phase agreement and frequency synchronization for arbitrary initial phases and/or frequencies under distributed control strategies.

DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.

Introduction: Extensive studies on SHP-1 protein and SHP-1 mRNA revealed that the diminishment or abolishment of the expression of SHP-1 in leukemias/lymphomas was due to aberrant promoter methylation. Thus far, the mechanism of epigenetic silencing of the SHP-1 tyrosine phosphatase gene that occurs in chronic myelogenous leukemia cells remains poorly understood.

Methods: The expressions of the target molecules were determined by quantitative real time PCR and western blot, respectively.

Epidemiologic survey on hospitalized neonates in China.

Objective: To carry out a nationwide epidemiologic survey on the neonates in urban hospitals with an attempt to understand the disease spectrum and treatment outcomes of hospitalized neonates in China.

Methods: The clinical data of 43,289 hospitalized neonates from 86 hospitals in 47 Chinese cities (22 provinces) between January 1, 2005 and December 31, 2005 were retrospectively analyzed.

Results: The male:female ratio was 1.