Publications by authors named "Xitong Tian"
Characterization of ribosome heterogeneity during endothelial to hematopoietic transition.
FEBS Open Bio
June 2025
Emerging evidence has demonstrated that ribosomes are not homogeneous structures with non-specialized functions. There are now several reports of heterogeneity in the composition and functional specialization of ribosomes. Ribosome heterogeneity functions in regulating the translation of specific mRNAs, and thus plays important roles in embryonic development.
View Article and Find Full Text PDFRibosome biogenesis is essential for hemogenic endothelial cells to generate hematopoietic stem cells.
Development
November 2024
Article Synopsis
- A small number of embryonic aortic endothelial cells transition into hemogenic endothelial cells (HECs), which are crucial for producing hematopoietic stem cells (HSCs).
- Researchers found that ribosome biogenesis (RiBi) activity is significantly higher in HECs compared to nearby endothelial cells and is essential for the formation of HSCs.
- Disruption of RiBi in HECs blocked HSC generation, while a transcription factor named Runx1 plays a key role in enhancing RiBi during this transition, suggesting that targeting RiBi could improve strategies for HSC regeneration.