Publications by authors named "Xin-Hong Xue"
Article Synopsis
- The study examined the effectiveness of metagenomic next-generation sequencing (mNGS) for diagnosing central nervous system (CNS) infections after patients received empirical treatment.
- The research involved analyzing 262 cerebrospinal fluid (CSF) samples, revealing that 69.84% were confirmed as CNS infections, predominantly viral and bacterial.
- Results indicated that mNGS had higher sensitivity (65.6%) and accuracy (72.0%) compared to conventional diagnostic methods, suggesting mNGS is a superior option for diagnosing CNS infections post-treatment.
Article Synopsis
- A 66-year-old male patient was diagnosed with suppurative meningitis caused by an anthropozoonotic infection after presenting with dizziness, nausea, and vomiting.
- Metagenomic next-generation sequencing (mNGS) revealed a simultaneous intracranial infection by two different types of bacteria, leading to a brain abscess.
- The case highlights the importance of considering mixed infections in patients with rare pathogens and suggests that mNGS can enhance conventional diagnostic methods in challenging cases.
Diagnostic utility of GDF15 in neurodegenerative diseases: A systematic review and meta-analysis.
Brain Behav
February 2022
Introduction: GDF15 may be a potential biomarker for neurodegenerative diseases. In this analysis, we aimed to quantitative analysis the levels of GDF15 in patients with neurological diseases and in health control, and then to determine its potential diagnostic utility.
Methods: Two researchers separately conducted a systematic search of the relevant studies up to January 2021 in Embase, PubMed, and Web of Science.
BACKGROUND Ischemia-reperfusion injury is caused by a blood reperfusion injury in ischemic brain tissue, and usually occurs in the treatment stage of ischemic disease, which can aggravate brain tissue injury. MiR-122 is closely related to ischemia-reperfusion injury in the myocardium, kidney, and liver; however, the role in cerebral ischemia-reperfusion injury has not been established. MATERIAL AND METHODS In this study, cerebral ischemia-reperfusion injury was established in a rat model, and the control group was a sham-operated group.
View Article and Find Full Text PDFThere are many risk factors for the cause of postoperative cognitive dysfunction (POCD), however, the anesthesia selection always trigger controversy for the POCD occurrence. This study aims to explore the relationship between the anesthesia and the occurrence of POCD in elder patients, and also investigate the mechanism of the POCD. One hundred elder patients with hip replacement were included in this study, which were divided into general anesthesia (GA) and epidural analgesia (EA) group.
View Article and Find Full Text PDF[Risk factors on the recurrence of ischemic stroke and the establishment of a Cox's regression model].
Zhonghua Liu Xing Bing Xue Za Zhi
August 2011
Objective: To investigate the risk factors and establish the Cox's regression model on the recurrence of ischemic stroke.
Methods: We retrospectively reviewed consecutive patients with ischemic stroke admitted to the Neurology Department of the Hebei United University Affiliated Hospital between January 1, 2008 and December 31, 2009. Cases had been followed since the onset of ischemic stroke.