Publications by authors named "Xiaorong Gou"
Compacting hyaluronan into nanogels induces an enhanced macropinocytosis in MC38 cells.
Int J Biol Macromol
May 2025
Hyaluronan (HA)-based drug delivery system including HA conjugates and nano-formulations have been intensively researched in various biomedical applications due to its excellent biocompatibility and unique biological characteristics. Currently most researches are exploring the targeted drug delivery enabled by HA receptors e.g.
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- - Treatment for triple negative breast cancer (TNBC) is difficult because there are few targeted therapies and the tumors themselves can vary a lot in features.
- - A combination of the chemotherapy drug cisplatin (Cis) and the SRC inhibitor dasatinib (DAS) can effectively fight TNBC but often leads to harmful side effects.
- - Researchers created a new hyaluronan (HA) nanogel (HCD) to encapsulate both Cis and DAS, which targets TNBC cells more effectively, enhances drug efficacy, increases the maximum tolerated dose, and reduces kidney toxicity in a mouse model.
Flow behavior and linear viscoelasticity of cellulose 1-allyl-3-methylimidazolium formate solutions.
Carbohydr Polym
January 2014
The rheological properties of α-cellulose 1-allyl-3-methylimidazolium formate solutions were investigated using shear viscosity and dynamic rheological measurements in a large range of concentrations (0.1-10 wt%) at 25 °C. In steady shear measurement, the overlap concentration (c*) and the entanglement concentration (c(e)) were determined to be 0.
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