Dissection of genetic basis underlying heat stress response of Apis cerana.

The honeybee Apis cerana as an important pollinator contributes significantly to ecological diversity. In recent years, it has been used as a common pollinator in greenhouses, but it is highly susceptible to heat stress, which affects its behavior, physiology, survival, and gene expression. Here, we conducted transcriptomic analysis to identify differentially expressed genes (DEGs) and reveal the associated biological processes in the queen head and ovary of honeybee A.

The Xanthomonas fragariae effector XopK suppresses stomatal immunity by perturbing abscisic acid accumulation and ABA-transciptional responses in strawberry.

Xanthomonas fragariae (Xaf) is the cause of strawberry crown dry cavity rot and strawberry leaf angular spots. Despite having a long evolutionary history with strawberries, the plant-pathogen interaction is poorly understood. Pathogenicity for most plant pathogens is mostly dependent on the type-III secretion system, which introduces virulence type III effectors (T3Es) into eukaryotic host cells.

Systemic Colonization of Strain YL19 Causing Dry Cavity Rot of Strawberry Crown Tissue in China.

usually causes angular leaf spot (ALS) of strawberry, a serious bacterial disease in many strawberry-producing regions worldwide. Recently, a new strain of (YL19) was isolated from strawberry in China and has been shown to cause dry cavity rot in strawberry crown. In this study, we constructed a green fluorescent protein (GFP)-labeled YL19 (YL19-GFP) to visualize the infection process and pathogen colonization in strawberries.

Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes.

Ferredoxin reductase (FDXR), a mitochondrial membrane-associated flavoprotein, is essential for electron transfer and modulates p53-dependent apoptosis in cancer cells.FDXR may be implicated in epidermal and sebocytic differentiation, but its explicit function in sebocytes remains to be elucidated. In the present study, immunohistochemistry revealed that FDXR expression was increased in sebaceous cells of acne lesions.

Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide analysis of copy number variation.

Background: The prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing and emerging as a global health burden. In addition to environmental factors, numerous studies have shown that genetic factors play an important role in the development of NAFLD. Copy number variation (CNV) as a genetic variation plays an important role in the evaluation of disease susceptibility and genetic differences.

Physical activity intervention for non-diabetic patients with non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials.

Background: Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease nowadays. Changes in diet and lifestyle have led to a dramatic increase in the prevalence of NAFLD around the world. This meta-analysis is to investigate the efficacy of physical activity intervention on liver-specific endpoints in the population with NAFLD, including hepatic enzyme, serum lipid, glucose metabolism and intra-hepatic lipid.

Strain-Tunable Electronic Properties and Band Alignments in GaTe/CN Heterostructure: a First-Principles Calculation.

Recently, GaTe and CN monolayers have been successfully synthesized and show fascinating electronic and optical properties. Such hybrid of GaTe with CN may induce new novel physical properties. In this work, we perform ab initio simulations on the structural, electronic, and optical properties of the GaTe/CN van der Waals (vdW) heterostructure.

[Oxidation of Humic Acid Complexing As(Ⅲ) by As(Ⅲ)-Oxidizing Bacteria].

The interaction between soil arsenic and soil microorganisms has been identified as one of the important parts of the morphological transformation of soil arsenic. In order to investigate the interaction between Humic Acid complexing As(Ⅲ)[HA-As(Ⅲ)] and As(Ⅲ)-oxidizing bacteria (HN-2), the changes in arsenic speciation in the liquid phase and the solid phase, with different pH, were studied. The results indicated there was better As(Ⅲ) oxidation efficiency in the pH 7 reaction system.

FoxO1 enhances differentiation and apoptosis in human primary keratinocytes.

Forkhead box-O1 (FoxO1) is a key nutrient- and growth factor-dependent regulator of metabolism, but its functional role in human primary keratinocytes (HPKs) is less known. To investigate the role of FoxO1 in HPKs and effect of insulin-like growth factor 1 (IGF-1) and isotretinoin on FoxO1 expression, HPKs were treated with 1.2 mmol/L calcium chloride, 1-20 ng/mL IGF-1 and 0.

Differentiation Model Establishment and Differentiation-Related Protein Screening in Primary Cultured Human Sebocytes.

Sebocyte differentiation is a continuous process, but its potential molecular mechanism remains unclear. We aimed to establish a novel sebocyte differentiation model using human primary sebocytes and to identify the expression profiles of differentiation-associated proteins. Primary human sebocytes were cultured on Sebomed medium supplemented with 2% serum for 7 days.

[Effects of Human Gut Microbiota on Bioaccessibility of Soil Cd, Cr and Ni Using SHIME Model].

The influence of human gut micobiota on bioaccessibilities of soil Cd, Cr, and Ni were investigated in this study. Five soil samples were collected from some sites of China, and the bioaccessibilities of soil Cd, Cr, and Ni in the gastric, small intestinal, and colon phases were determined using the PBET method (physiologically based extraction test) combined with SHIME model (simulator of human intestinal microbial ecosystem). The results showed that the bioaccessibilities of Cd, Cr, and Ni in the gastric phase were 4.