Bilateral Unsymmetrical Disulfurating Reagent Design for Polysulfide Construction.

Polysulfides are significant compounds in life science, pharmaceutical science, and materials science. Therefore, polysulfide construction is in great demand. The controllable sequential installation of groups on both ends of a S-S motif faces an enormous challenge owing to the reversible nature of the covalent S-S bond.

Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp C-H Functionalization.

An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl ()-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attractive. Moreover, this method can simultaneously construct two molecular fragments of chromone and indolizine.

Cascade Wolff Rearrangement/Acylation: A Metal-Free and Eco-Friendly Approach for 4-Hydroxy-pyrazolo[3,4-]pyridin-6-ones and -Pyrazole Amides Synthesis from 5-Aminopyrazoles and α-Diazoketones.

A highly chemoselective cascade Wolff rearrangement/acylation reaction between 5-aminopyrazoles and diazo compounds has been developed. The protocol can facilitate the switchable synthesis of 4-hydroxy-pyrazolo[3,4-]pyridin-6-ones and -pyrazole amides with the merits of a broad substrate scope, high functional group compatibility, and green and sustainable performance manner. All reactions proceeded efficiently without any catalyst and additives (acid and base) and resulted in the release of benign N, wherein diethyl carbonate served as a green benign solvent.

One-Pot Synthesis of Chromone-Fused Pyrrolo[2,1-]isoquinolines and Indolizino[8,7-]indoles: Iodine-Promoted Oxidative [2 + 2 + 1] Annulation of -Acetylphenoxyacrylates with Tetrahydroisoquinolines and Noreleagnines.

An iodine-promoted one-pot cascade oxidative annulation reaction has been developed for the synthesis of chromone-fused-pyrrolo[2,1-]isoquinolines and indolizino[8,7-]indoles from -acetylphenoxyacrylates, tetrahydroisoquinolines, and noreleagnines. This process underwent a logical approach to both chromone-fused-pyrrolo[2,1-]isoquinolines and chromone-fused-indolizino[8,7-]indoles isolamellarin derivatives. Manipulations of l-menthol and dl-α-tocopherol demonstrate the applications of this strategy.