Publications by authors named "Wouter Huiting"
Background: Beneficial effects of whole-body vibration (WBV) on brain and musculoskeletal health in mice have been demonstrated, but underlying mechanisms remain relatively unrevealed. WBV improves attention and memory performance in mice, putatively through stimulation of the cholinergic system. Here, we investigated the effects of WBV on the septo-hippocampal cholinergic system.
View Article and Find Full Text PDFMacroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation. Autophagosome biogenesis depends on the core autophagy-related (Atg) machinery, and involves a massive supply and remodelling of membranes. To gain insight into the lipid remodelling mechanisms during autophagy, we have systematically investigated whether lipid flippases are required for this pathway in the yeast .
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- * Targeting ATM, ATR, or DNA topoisomerases can cause significant aggregation of proteins, particularly those prone to aggregation such as Huntingtin with an expanded polyglutamine repeat, due to a breakdown in cellular chaperone systems.
- * Inhibition of the HSP70 chaperone system worsens protein aggregation, while the chaperone HSPB5 can help suppress this aggregation, indicating a connection between genotoxic stress and protein aggregation similar to conditions seen in protein-related diseases.
Article Synopsis
- Genome instability and loss of protein homeostasis play significant roles in age-related neurodegenerative diseases like Alzheimer’s and Parkinson’s, often leading to protein aggregation and impacted DNA damage responses.
- The review explores how these two cellular processes affect each other, noting that DNA damage can increase in neurodegenerative patients due to the presence of protein aggregates, which may disrupt DNA repair mechanisms.
- Understanding the relationship between protein homeostasis and genome stability is crucial, as it could pave the way for new therapies targeting these interconnected issues in neurological disorders.
Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed Polycomb group protein (PcG) complex integrity in response to heat shock (HS). Upon HS, various Polycomb Repressive Complex (PRC)1 and PRC2 subunits, including CBX proteins, but also other chromatin regulators, are found to accumulate in the nucleolus.
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