Timeline of Amelogenesis Imperfecta Management.

Amelogenesis imperfecta is a heterogeneous group of >100 different rare diseases. Affected individuals and families are facing diagnostic uncertainty and wandering and a therapeutic odyssey. Continuous multidisciplinary management from childhood to adulthood is essential, emphasizing the critical role of health care professionals.

Dental Adverse Effects Following Multimodality Treatment for Head and Neck Rhabdomyosarcoma: Results of a Trans-Atlantic Multicentre Study.

Introduction: As survival of paediatric cancer improves, more emphasis is placed on late adverse effects. However, the dental and periodontal adverse effects of cancer treatments in children remain an underinvestigated complication. This study aims to investigate the prevalence of late clinical dental adverse effects (cDAE) in survivors of paediatric head and neck rhabdomyosarcoma (HNRMS).

Implant supported overdentures in Sjögren's disease patients: a multicentre prospective cohort study.

Objectives: To prospectively investigate patient-reported outcomes and clinical performance of implant supported overdentures in edentulous Sjögren's disease (SjD) patients compared to subjects without SjD.

Methods: 51 implants were placed in 12 patients with SjD and 50 implants in 12 non-SjD patients to support overdentures. Clinical performance, marginal bone-level changes, patient satisfaction and oral health related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12) and 18 (T18) months after placement of the overdenture.

Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study.

Objectives: To prospectively assess the clinical performance and patient-reported outcomes of dental implants in dentate patients with primary and secondary Sjögren's syndrome (pSS and sSS, respectively) compared to patients without SS.

Materials And Methods: Thirty-seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non-SS patients to replace missing (pre)molars. Clinical performance, marginal bone-level changes, patient satisfaction, and oral health-related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure.

Gastrointestinal symptoms in patients with isolated oligodontia and a Wnt gene mutation.

Objective: Since Wnt signaling plays an important role in both tooth agenesis and altered intestine homeostasis, the aim was to compare gastrointestinal symptoms in patients with isolated oligodontia caused by a Wnt pathway gene mutation and controls.

Methods: A case-control study was designed to compare self-reported gastrointestinal symptoms among patients with isolated oligodontia, caused by a Wnt signaling gene mutation, and fully dentate controls. The Gastrointestinal Symptom Rating Scale (GSRS) was used to assess gastrointestinal symptoms.

Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.

Tooth agenesis is one of the most common developmental anomalies in man. Oligodontia, a severe form of tooth agenesis, occurs both as an isolated anomaly and as a syndromal feature. We performed exome sequencing on 20 unrelated individuals with apparent non-syndromic oligodontia and failed to detect mutations in genes previously associated with oligodontia.

Tooth loss prior to radiation in relation to tumor location in patients with head and neck cancer.

Purpose: This study aimed to investigate the impact of preradiation tooth loss in patients with head and neck cancer.

Materials And Methods: Records of 397 (partially) dentate patients who were referred for preradiation oral screening were included. Number and location of teeth lost and occluding pairs lost were determined for different tumor locations.

Shear resistance of fiber-reinforced composite and metal dentin pins.

Purpose: To assess whether dentin pins increase shear resistance of extensive composite restorations and to compare performance of mini fiber-reinforced composite (FRC) anchors with metal dentin pins in the laboratory.

Methods: 30 extracted sound molars were randomly divided into three groups. Occlusal surfaces were ground flat with a standard surface area and resin composite restorations were made in Group A.

In vitro repair of fractured fiber-reinforced cusp-replacing composite restorations.

Objective. To assess fracture resistance and failure mode of repaired fiber-reinforced composite (FRC) cusp-replacing restorations. Methods.

Microhardness of resin composite materials light-cured through fiber reinforced composite.

Objectives: To compare polymerization efficiency of resin composite basing materials when light-cured through resin composite and fiber reinforced composite (FRC) by testing microhardness.

Methods: Simulated indirect restorations were prepared by application of resin composite (Clearfil AP-X) or FRC (EverStick) to nylon rings with 1.5mm thickness and 8mm diameter, followed by light-curing.

In vitro fracture resistance of fiber reinforced cusp-replacing composite restorations.

Objectives: To assess the fracture resistance and failure mode of fiber reinforced composite (FRC) cusp-replacing restorations in premolars.

Methods: Forty-five extracted sound upper premolars were randomly divided into three groups. Identical MOD cavities with simulated buccal cusp fracture and height reduction of the palatal cusp were prepared.

Fatigue resistance of teeth restored with cuspal-coverage composite restorations.

Purpose: This study assessed the influence of palatal cuspal coverage on the in vitro fatigue resistance and failure mode of Class II resin composite restorations including replacement of the buccal cusp in premolars.

Materials And Methods: A master model was made of a maxillary premolar with an MOD amalgam cavity and a simulated fracture of the buccal cusp from the isthmus floor to the CEJ. Using a copy-milling machine, this preparation was copied to 20 extracted human maxillary premolars (group A).

Fracture strength of cusp replacing resin composite restorations.

Purpose: To assess the influence of an additional shoulder preparation on the fracture strength of a cusp-replacing direct resin composite restoration in a premolar that previously had an amalgam MOD restoration followed by fracture of a cusp.

Materials And Methods: Two preparation designs were tested. In extracted sound premolars an MOD amalgam cavity was simulated followed by fracture of a cusp (Group A).

A survey of cusp fractures in a population of general dental practices.

Purpose: This study was conducted to expand the knowledge on the incidence of complete cusp fractures of posterior teeth in Dutch general practices.

Materials And Methods: During a 3-month period, data were obtained from 28 general practitioners, representing 46,394 patients. For each new case of complete cusp fracture, clinicians recorded information using a standard form with questions relating to location of the fracture, cause of fracture, and restorative status of the tooth prior to the cusp fracture.