Synergistic inhibition of pathogenic fungi by oleanolic acid combined with azoles.

Invasive fungal infections and emerging antifungal resistance mediated by pathogenic fungi, notably spp., spp., , and pose a critical challenge to global public health systems.

-a novel zinc finger transcription factor involved in azole resistance.

Elucidating the mechanisms underlying antifungal resistance in , discovering new antifungal targets, and developing drugs to inhibit resistance are the key approaches to treating infections. Here, we investigated the function of (AFUA_1G03800), a gene encoding a C6 transcription factor. Homologous recombination replacement technology was employed to construct knockout and revertant strains.

Observation of a Bone Invasion Model of Aspergillus fumigatus In Vitro and Analysis of the Antifungal Susceptibility.

Background: Recently, the prevalence of invasive fungal infections has been on the rise, and one of the prevalent symptoms frequently observed is bone deterioration and bone loss.

Materials And Methods: Using an in vitro model we studied how Aspergillus fumigatus invades the bone. Pathological analysis was then employed to observe the structure and distinctive features of the invading fungal elements within the bone invasion model.

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy.

Lung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy have also been applied in the clinics.