Key markers and detection methods for evaluating platelet dysfunction in mechanical circulatory support devices.

Mechanical circulatory support devices (MCSDs) have emerged as life-saving interventions for patients with end-stage heart failure. However, the non-physiological shear stress (NPSS) generated by MCSDs is a known precipitant of platelet dysfunction, augmenting risks of thrombotic and bleeding complications. Addressing this issue necessitates innovative approaches to attenuate platelet dysfunction, thereby enhancing the safety of MCSDs.

Research on the Influence of Microstructured Surface Characterization Parameters on Blood Damage.

Background: Mechanical circulatory support devices (MCSDs) are among the most effective treatments of end-stage heart failure. Despite their efficacy, patients often experience hemocompatibility issues such as hemolysis and gastrointestinal bleeding caused by blood damage. The surface characteristics of blood-contacting materials significantly affect hemocompatibility, and designing specific surface microstructures may help mitigate blood damage.

The influence of arterial stenosis on blood damage under continuous flow.

Arterial stenosis, resulting from plaque accumulation, can lead to serious conditions such as thrombosis and von Willebrand syndrome. This study investigates how variations in stenosis shape and severity affect red blood cell (RBC) and von Willebrand factor (VWF) damage through simulations and experimental approaches. A continuous flow generation device was utilized to create a blood circulation platform.

The Impact of Mechanical Circulatory Support Devices on White Blood Cell Phenotype and Function.

Background: Mechanical circulatory support devices (MCSDs) have gradually become an effective treatment of end-stage heart failure (HF). However, the introduction of foreign surfaces and non-physiological shear stress (NPSS) can cause severe damage to various blood cells, leading to impaired function of immune system and increased risk of complications such as inflammation and thrombosis. The effect of mechanical injury on white blood cell (WBC) has been largely neglected compared to that on red blood cell (RBC) and platelet (PLT).

In vitro comparative study of red blood cell and VWF damage on 3D printing biomaterials under different blood-contacting conditions.

Mechanical circulatory support devices (MCSDs) are often associated with hemocompatible complications such as hemolysis and gastrointestinal bleeding when treating patients with end-stage heart failure. Shear stress and exposure time have been identified as the two most important mechanical factors causing blood damage. However, the materials of MCSDs may also induce blood damage when contacting with blood.