Contributions of the elderly to the transmission of HIV/AIDS in China.

In recent years, the number of HIV/AIDS cases shows an upward trend in China, particularly among the elderly, exerting severe effects on public health and social economy. This paper proposes an HIV/AIDS model incorporating sexual transmission and age structure to study the influence of the elderly on HIV/AIDS spread. Theoretically, the explicit expression for the basic reproduction number is obtained, the globally asymptotically stability of disease-free equilibrium and existence and uniqueness of boundary equilibrium are proved.

Baicalin Enhances Chemosensitivity to Doxorubicin in Breast Cancer Cells via Upregulation of Oxidative Stress-Mediated Mitochondria-Dependent Apoptosis.

Doxorubicin (Dox) is an effective anthracycline anticancer drug. However, recent studies have revealed that Dox resistance is a highly critical issue, and a significant reason for treatment failure. Baicalin is a flavonoid component in the roots of Georgi; however, whether baicalin can increase chemosensitivity in breast cancers is still unclear.

Effects of Exercise in Patients Undergoing Chemotherapy for Head and Neck Cancer: A Pilot Randomized Controlled Trial.

Background: Cisplatin administration may induce muscle atrophy, thereby reducing the fitness level of patients with head and neck cancer (HNC). To date, only animal studies have been conducted to test the effectiveness of exercise interventions in diminishing side effects of cisplatin.

Aim: To determine whether exercise training improves physical fitness and health-related quality of life (HRQoL) in patients receiving chemotherapy for Head & Neck (H&N).

[Relationship between natural extinction of snails and water chemical properties in Eastern Dongting Lake areas].

Objective: To investigate the reasons of natural extinction of snails by comparing the difference of the water chemical properties between the snail-breeding marshland and non-snail marshland in Eastern Dongting Lake areas.

Methods: Three adjoining marshlands in Eastern Dongting Lake areas were selected, one was a snail-breeding marshland, the second was a non-snail marshland, and the third was a boundary zone between them. During the periods of water-rising season, wet season and water-falling season, the water samples from the bottom of 0.

Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and in Yi People.

Objective: To explore the association between infections with HIV and , and to determine the influences of the HIV- coinfections on the immune system of Yi people.

Methods: A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and in China. All participants were screened for HIV antibodies and antibodies (SjAb) and were classified into four groups: HIV(+)/(-), HIV(-)/ (+), HIV(+)/(+), and HIV(-)/(-).

[Research on living status of in autumn and winter and its correlates in Eastern Dongting Lake area].

Objective: To explore the dynamic changes of snail densities in autumn and winter and the relationship between hydrological and meteorological factors and snail growth and decline.

Methods: From Octobers to Decembers of 2007 to 2014, a bottomland close to eastern Dongting Lake was selected as the study field. The snails and elevation of the points were surveyed, and the hydrological and meteorological data were collected.

[Temporal and spatial distribution of infection of population and its risk factors in Eastern Dongting Lake area in 2012 and 2014].

Objective: To investigate the temporal and spatial distribution of infection of population and its risk factors in Eastern Dongting Lake area in 2012 and 2014, so as to provide the reference for formulating effective intervention measures.

Methods: Junshan District was selected as a study field in Eastern Dongting Lake area. The method of spatial autocorrelation analysis was applied to analyze the change of spatial distribution of infection in Junshan District in 2012 and 2014.

Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells.

Protein phosphatase 2A is one of four major classes of serine/threonine phosphatases. Overexpression of brain-specific regulatory subunit PPP2R2 in neuron cells is implicated in pathogenesis. The alternative splicing of PPP2R2B encodes two isoforms.

Oxidative stress promotes autophagic cell death in human neuroblastoma cells with ectopic transfer of mitochondrial PPP2R2B (Bbeta2).

Background: The multifunctional protein phosphatase 2A (PP2A) is a heterotrimeric serine/threonine protein phosphatase composed of a scaffolding, catalytic and regulatory subunits. By modifying various downstream signal transducers, the aberrant expression of the brain-targeted regulatory subunit PPP2R2B is associated with the onset of a panel of neuronal disorders. The alternatively splicing of PPP2R2B encodes two regulatory subunit isoforms that determine cellular distribution of the neuron-specific holoenzyme to mitochondria (Bbeta2) and cytoplasm (Bbeta1), respectively.