Publications by authors named "Viola Roehrs"
Three-dimensional (3D) bioprinting is one of the most promising methodologies that are currently in development for the replacement of animal experiments. Bioprinting and most alternative technologies rely on animal-derived materials, which compromises the intent of animal welfare and results in the generation of chimeric systems of limited value. The current study therefore presents the first bioprinted liver model that is entirely void of animal-derived constituents.
View Article and Find Full Text PDFGeneration of a Perfusable 3D Lung Cancer Model by Digital Light Processing.
Int J Mol Sci
March 2023
Article Synopsis
- - Lung cancer remains a leading cause of death and its incidence is rising, particularly in developing countries, demonstrating an urgent need for new treatment options despite advancements in targeted therapies.
- - A novel non-small cell lung cancer model was developed using digital light processing (DLP), incorporating simulated human blood vessels to facilitate drug testing in a more relevant environment.
- - Initial studies showed that the bioprinted 3D model had significantly higher cell viability and drug response compared to traditional 2D cultures, indicating its potential for testing new anticancer drugs, although further refinement is needed for comprehensive drug characterization.
3D-bioprinted HepaRG cultures as a model for testing long term aflatoxin B1 toxicity .
Toxicol Rep
November 2020
In recent years 3D-bioprinting technology has been developed as an alternative to animal testing. It possesses a great potential for testing as it aims to mimic human organs and physiology. In the present study, an alginate-gelatin-Matrigel based hydrogel was used to prepare 3D-bioprinted HepaRG cultures using a pneumatic extrusion printer.
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