A metagenomic approach to predict the role of microbiome in a plant-microbe system for degrading the model azo dye methyl red.

Azo dye contamination poses significant environmental challenges due to its persistence and toxicity. Plant-microbe integrated systems offer a sustainable solution for dye bioremediation, yet the functional roles of microbial communities and their interactions within community and with host plants during bioremediation remain underexplored. This study presents an integrated, multi omics approach to dissect the microbial diversity, functional potential, and plant-microbe interactions within a plant-microbe integrated bioremediation system for model azo dye, methyl red degradation.

Automated weed and crop recognition and classification model using deep transfer learning with optimization algorithm.

Weeds and crops contribute to a endless resistance for similar assets, which leads to potential declines in crop production and enlarged agricultural expenses. Conventional models of weed control like extensive pesticide use, appear with the hassle of environmental pollution and advancing weed battle. As the need for organic agricultural and pollutant-free products increases, there is a crucial need for revolutionary solutions.

The network map of mucin 1 mediated signaling in cancer progression and immune modulation.

Mucin 1 (MUC1) is a type-I transmembrane glycoprotein, ranked as the second most promising cancer antigen for therapeutic development by the National Cancer Institute. Recently, MUC1 has gained significant attention as a therapeutic target in cancer immunotherapy. Thus, understanding MUC1-regulated signaling is essential for advancing therapeutic strategies.

An assembled molecular signaling map of interleukin-24: a resource to decipher its multifunctional immunoregulatory role in pathophysiological conditions.

Introduction: Interleukin-24 (IL-24) is a cytokine belonging to the IL-10 family with immunoregulatory properties. It is known to induce cellular responses in various disease conditions, including inflammatory, infectious diseases, and cancer, in a receptor-dependent and independent manner. IL-24 is induced by both immune and non-immune cells and acts on a vast array of target cells to regulate various biological processes.

A comparative study on optical trocar entry vs. balloon trocar entry in laparoscopic eTEP inguinal hernia repair - a randomised control trial.

Background: The enhanced Totally Extra-Peritoneal (eTEP) technique is a novel minimally invasive approach to inguinal hernia repair that involves entry into the retro-rectus space and dissection of preperitoneal spaces. Aim of this study is to compare two methods for creating the preperitoneal space: optical trocar dissection (Group A) and balloon trocar dissection (Group B).

Materials And Methods: A prospective, single-blinded, interventional study was conducted with 116 patients, randomized into two groups (58 in each group) undergoing eTEP inguinal hernia repair at SRM Medical College Hospital, India.

Exploring the acceptability, feasibility and utility of a digital tool for self-reporting perinatal anxiety and depression in urban obstetric and paediatric clinics in India.

Background: Common mental disorders, such as anxiety and depression, affect 13% to 55% of women during the perinatal period in India. However, high-volume obstetric clinics often lack resources for routine mental health assessment. Digital tools could address this gap by facilitating maternal mental health screening.

Exploring sulphated polysaccharides from marine bivalves: Unveiling potent anti-gastric cancer activity through cell cycle arrest and apoptosis.

This study investigates the extraction of partially purified sulphated polysaccharides from marine bivalves through enzymatic digestion followed by sequential deproteinization and evaluates their anti-gastric cancer activity. Chemical analysis confirmed high uronic acid and sulfate content, with FT-IR validating characteristic functional groups. polysaccharide demonstrated significant, dose-dependent anti-proliferative effects against AGS cells.

Carotid intima medial thickness and its association with cardiometabolic risk factors in children with overweight and obesity: a hospital-based cross-sectional study.

A hospital-based cross-sectional study involving children aged 2-15 years attending the obesity clinic of a tertiary care hospital from January 2016 to March 2018 was carried out to study carotid intima media thickness (cIMT) and its association with cardiometabolic risk factors in children with overweight and obesity. Secondary objective was to compare children with elevated (EcIMT) and normal cIMT (NcIMT). Out of 223 patients enrolled for the study, 102 (45·7 %) had EcIMT.

Proteomic profiling of oral squamous cell carcinoma tissues reveals altered immune-related proteins: implications for personalized therapy.

Objectives: Oral squamous cell carcinoma poses a substantial global health challenge marked by rising mortality rate. Recently, immunotherapy has shown promising results in cancer management by enhancing immune response. Thus, identifying additional immune-related markers is critical for advancing immunotherapy treatments.

Engineering the Coordination Environment in the Silver(I)- and Ruthenium(II)--Heterocyclic Carbene Complexes in Instigating the Electrocatalytic Hydrogen Evolution Reaction.

The quest for cost-efficient and high-performance electrocatalysts towards electrocatalytic water splitting is a key and an interdisciplinary area of study. Considerable progress is being driven by developments in the field of energy research. In a fundamental study, we have synthesized NHC precursors ( and ) and corresponding metal-NHC complexes of silver(I)- ( and ) and ruthenium(II)- ( and ) of a N-heterocyclic carbene-based ligand type incorporating coumarins.

Depression among older adults who developed acute coronary syndrome (ACS) during hospitalization for non-cardiac illness: A prospective observational study.

Background: Atypical presentations of ACS delay its recognition and treatment in the older adults. During hospitalization, depression and functional decline, which is unique to older adults, leads to poor clinical outcome. Steps taken for its prevention is unlikely to become a priority for the Cardiologist.

What to do with a protruding coronary stent in the aorta?

Coronary artery stents protruding into the aorta is a rarely reported problem. Issues with the protruding stent include embolization and interference with aortic valve function. Management of this rare situation should be on an individualized basis.

Proteomic analysis of peripheral blood mononuclear cells from OSCC patients reveals potential immune checkpoints to enable personalized treatment.

Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide, with high mortality and prevalence rates. OSCC is defined as an immunogenic tumor with the potential to be recognized and targeted by the immune system. It is characterized by the extensive infiltration of immune cells and plays a vital role in tumorigenesis.

Preclinical evaluation of dalbergin loaded PLGA-galactose-modified nanoparticles against hepatocellular carcinoma via inhibition of the AKT/NF-κB signaling pathway.

Prior research has shown the effectiveness of dalbergin (DL), dalbergin nanoformulation (DLF), and dalbergin-loaded PLGA-galactose-modified nanoparticles (DLMF) in treating hepatocellular carcinoma (HCC) cells. The present investigation constructs upon our previous research and delves into the molecular mechanisms contributing to the anticancer effects of DLF and DLMF. This study examined the anti-cancer effects of DL, DLF, and DLMF by diethyl nitrosamine (DEN)-induced HCC model in albino Wistar rats.

Dy ions infused modifier reliant boro-phosphate glasses: A promising host for W-LED demand.

An exclusive set of Dy ions incorporated Boro-phosphate glasses with different modifier ions like Sr, Mg, Ba, Li and Zn have been manufactured by quenching the melts. The optical behavior of the present glasses was explored through absorption, luminescence & lifetime studies. Physical parameters such as refractive index (RI) and density have been calculated and utilized to evaluate other parameters.

Estimating the Reliability and Validity of the Quadrant Hop Test in the Assessment of the Functional Stability of the Knee.

Background Many sporting activities demand multidirectional skills and movements, emphasizing the importance of various fitness components such as functional stability, strength, power, endurance, and range of motion. These aspects must be thoroughly assessed before athletes can return to sports safely following an injury. Although the single-leg hop test (SHT) is widely used as the gold standard for evaluating joint stability, it has limitations in assessing multidirectional movements.

Author Response.

Vijayakumar M, Selvam V, Renuka MK, Rajagopalan RE. Author Response. Indian J Crit Care Med 2024;28(5):512.

Author Response.

Vijayakumar M, Selvam V, Renuka MK, Rajagopalan RE. Author Response. Indian J Crit Care Med 2024;28(5):515.

REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker status.

The differential expression of plasma membrane proteins is integrally analyzed for their diagnosis, prognosis, and therapeutic applications in diverse clinical manifestations. Necessarily, distinct membrane protein enrichment methods and mass spectrometry platforms are employed for their global and relative quantitation. First of its kind to explore, we compiled membrane-associated proteomes in human and mouse systems into a database named, Resource of Experimental Membrane-Enriched Mass spectrometry-derived Proteome (REMEMProt).

Early and long-term outcomes of mitral valve replacement with mechanical valve in rheumatic heart disease.

Background: Rheumatic fever and rheumatic heart disease is endemic in India. Mitral valve replacement with mechanical valve is the commonest surgical procedure performed in rheumatic heart disease (RHD). However, there are no studies reporting the long-term outcomes of mechanical mitral valve replacement in rheumatic heart disease from India.

Evaluation of Natural Antimicrobial Substances Blend as a Replacement for Antibiotic Growth Promoters in Broiler Chickens: Enhancing Growth and Managing Intestinal Bacterial Diseases.

In recent years, commercial use of antibiotic growth promoter (AGP) has restrictions due to drug resistance against intestinal pathogenic bacteria: Escherichia coli, Salmonella, and Clostridium perfringens. Currently there is no single non-antibiotic treatment approach that is effective against intestinal illnesses in broiler chicken. Hence, present study aimed to analyze efficacy of blend of natural antimicrobial substances (probiotics, prebiotics, organic acids, and essential oils blend named as AGPR) as replacers of AGPs (BMD and CTC) for promoting growth and controlling bacterial diseases in aforementioned three microbes challenged broiler chickens.

The Comparative Efficacy of Ceftazidime-Avibactam with or without Aztreonam vs Polymyxins for Carbapenem-resistant Enterobacteriaceae Infections: A Prospective Observational Cohort Study.

Background: Carbapenem-resistant enterobacteriaceae (CRE) is associated with high mortality in critically ill patients, with limited treatment options. This study aims to compare clinical response, microbiological response, and mortality in patients treated with ceftazidime-avibactam with or without aztreonam (CAZ-AVI + AZT) and colistin or polymyxin B (polymyxins) in CRE infections.

Materials And Methods: This single-center prospective observational study included adult patients with CRE infections treated with CAZ-AVI+AZT or polymyxins between January 2022 and December 2022 at a Tertiary Care Medical Center in India.