Publications by authors named "Veronica Pinnaro"
The soluble cytoplasmic tail of the prototypic receptor-like protein tyrosine phosphatase (PTP) CD45 (ct-CD45) is cleaved and released into the human plasma by activated phagocytes. Released ct-CD45 was found to inhibit T cell proliferation and cytokine production via engagement of Toll-like receptor 4 (TLR4). In this study, we analyzed the impact of the ct-CD45/TLR4 pathway on the function of human monocyte-derived dendritic cells (DCs).
View Article and Find Full Text PDFDevelopment of Amniotic Epithelial Stem Cells Secretome-Loaded Inverse Electron Demand Diels-Alder-Cross-Linked Hydrogel as a Potential Immunomodulatory Therapeutical Tool.
ACS Appl Mater Interfaces
January 2025
Article Synopsis
- Amniotic epithelial stem cells (AEC) have regenerative potential, particularly through their conditioned medium (AEC-CM), which shows immunomodulatory and regenerative effects.
- A novel hydrogel made from hyaluronic acid and polyethylene glycol was developed to encapsulate AEC-CM, with features like fast cross-linking and sustained growth factor release over 14 days.
- Studies demonstrate that the encapsulated AEC-CM significantly enhances the suppression of peripheral blood mononuclear cells and promotes a shift towards the beneficial M2 macrophage phenotype, suggesting its viability as an immunomodulatory treatment for tissue regeneration.
Tendinopathies are a major worldwide clinical problem. The development of tendon biomimetic scaffolds is considered a promising, therapeutic approach. However, to be clinically effective, scaffolds should avoid immunological recognition.
View Article and Find Full Text PDFInflammation is a driving force of tendinopathy. The oxidation of phospholipids by free radicals is a consequence of inflammatory reactions and is an important indicator of tissue damage. Here, we have studied the impact of oxidized phospholipids (OxPAPC) on the function of human tenocytes.
View Article and Find Full Text PDFCancer is one of the greatest public health challenges. According to the World Health Organization (WHO), 9.6 million cancer deaths have been reported in 2018.
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