Spiradenocylindroma: Morphology of a Rare Hybrid Adnexal Tumor.

Spiradenocylindroma is a rare benign adnexal tumor with features of both spiradenoma and cylindroma, the scalp and face being the most common sites. They are considered to arise from pluripotent cells of abortive adnexal primordial tissue. Fine needle aspiration cytology, along with cell block, can give clues regarding the diagnosis.

Unlocking Key Intermediates in Copper-Catalyzed CO to Methanol Conversion.

Although copper catalysts have been widely employed in various catalytic transformations, their potential for converting CO to methanol remains largely unexplored to date. Herein, it is reported that a copper(I) salt efficiently converts CO into methanol equivalent in the presence of NaBH and an amide ligand (L1) under mild reaction conditions. The in situ generated active catalyst in the reaction is isolated as a single crystal and the structure solution reveals the formation of a reactive two-coordinate Cu(I) dimeric catalyst [Li(THF)Cu(L1)] (1).

Engineering an Agro-Infectious Apple Stem Grooving Virus Clone for Virus-Induced Gene Silencing (VIGS) in Plants.

Apple stem grooving virus (ASGV) is an important pathogen with a broad host range, infecting both monocot and dicot species, making it a promising candidate for virus-induced gene silencing (VIGS) applications in functional genomics. In this study, we developed an infectious cDNA clone of an ASGV apple isolate and demonstrated its infectivity across 10 diverse plant species from families' including Solanaceae, Fabaceae, Cucurbitaceae, and Amaranthaceae. The clone also successfully infected woody hosts such as Citrus limon and Malus domestica, and resulted in systemic infection through back-inoculation in Cucumis sativus, thereby fulfilling Koch's postulates.

Amelioration of Ulcerative Colitis in BALB/c Mice by Probiotic-Fermented Juice.

has been used traditionally in folk medicine for the treatment of gastrointestinal (GI) disorders. Fermentation using probiotics is well established to positively modulate the GI system. This study investigated the therapeutic potential of probiotic-fermented juice for ulcerative colitis (UC), using a mouse model.

Quantifying Magnetic Anisotropy of Series of Five-Coordinate Co Ions: Experimental and Theoretical Insights.

Stabilizing large easy-axis type magnetic anisotropy in molecular complexes is a challenging task, yet it is crucial for the development of information storage devices and applications in molecular spintronics. Achieving this requires a deep understanding of electronic structure and the relationships between structure and properties to develop magneto-structural correlations that are currently unexplored in the literature. Herein, a series of five-coordinate distorted square pyramidal Co complexes [Co(L)(X)].

Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria.

Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism. The generation of free radicals in the Class Ib ribonucleotide reductases is mediated by di-manganese ions in the β subunits and is externally assisted by flavodoxin-like NrdI subunit. This is unlike Class Ia ribonucleotide reductases, where the free radical generation is initiated at its di-iron centre in the β subunits with no external support from another subunit.

Utilization of Quince Peel and Exploration of Its Metabolite Profiling and Cardioprotective Potential Against Doxorubicin-Induced Cardiotoxicity in Wistar Rats.

Quince ( Mill.) is a pomaceous fruit that is typically processed into jams, jellies, and marmalade. The byproduct, i.

Victims of armed conflict in India: psychosocial impact and available support.

India has been a part of 5 major wars since its independence in 1947 and hosts over 212,413 refugees from Sri Lanka, Tibet and Bangladesh. So, a wide spectrum of trauma survivors, both civilian and military, live in this country and require mental healthcare. We discuss the psychological impact of armed conflict and how the country and culture tint it uniquely.

Effect of roasting and frying treatments on aflatoxins and capsaicinoids content and nutritional profile of green chilies ( L.).

This study was conducted to assess the effect of two thermal treatments, viz. roasting and pan frying (deep frying), on nutritional profile, aflatoxin, and capsaicin content in green chilies. Green chilies were subjected to roasting and frying to reduce the aflatoxin contamination, besides retaining their pungency and nutritional profile.

RGB colorimetric method based detection of oxytocin in food samples using cysteamine functionalized gold nanoparticles.

In the present investigation, a colorimetric method has been demonstrated for detection of oxytocin using Cysteamine functionalized gold nanoparticles (Cys-AuNP). The analyte oxytocin which finds its use in medical field is purposefully injected in fruits and vegetables for their faster growth. Also, it is used in the milk letdown in cattles.

Deciphering the Potential of Pre and Pro-Vitamin D of Mushrooms against Mpro and PLpro Proteases of COVID-19: An In Silico Approach.

Vitamin D's role in combating the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the virus causing COVID-19, has been established in unveiling viable inhibitors of COVID-19. The current study investigated the role of pre and pro-vitamin D bioactives from edible mushrooms against Mpro and PLpro proteases of SARS-CoV-2 by computational experiments. The bioactives of mushrooms, specifically ergosterol (provitamin D), 7-dehydrocholesterol (provitamin-D), 22,23-dihydroergocalciferol (provitamin-D), cholecalciferol (vitamin-D), and ergocalciferol (vitamin D) were screened against Mpro and PLpro.

The mA reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay.

The role of N6-methyladenosine (mA) modifications has increasingly been associated with a diverse set of roles in modulating viruses and influencing the outcomes of viral infection. Here, we report that the landscape of mA deposition is drastically shifted during Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection for both viral and host transcripts. In line with previous reports, we also saw an overall decrease in host methylation in favor of viral messenger RNA (mRNA), along with 5' hypomethylation and 3' hypermethylation.

THAP9 Transposase Cleaves DNA via Conserved Acidic Residues in an RNaseH-Like Domain.

The catalytic domain of most 'cut and paste' DNA transposases have the canonical RNase-H fold, which is also shared by other polynucleotidyl transferases such as the retroviral integrases and the RAG1 subunit of V(D)J recombinase. The RNase-H fold is a mixture of beta sheets and alpha helices with three acidic residues (Asp, Asp, Glu/Asp-DDE/D) that are involved in the metal-mediated cleavage and subsequent integration of DNA. Human THAP9 (hTHAP9), homologous to the well-studied Drosophila P-element transposase (DmTNP), is an active DNA transposase that, although domesticated, still retains the catalytic activity to mobilize transposons.

Dental Caries, Body Mass Index, and Socioeconomic Status among Preschoolers in Private Preschools and Anganwadi Centers in Bengaluru City: A Comparative Study.

Aim: Preschool is the time when deleterious oral habits, caries pattern, and risk factor are established and is the time to intervene and establish healthy trends which can have a lifelong influence. Individuals living in various socioeconomic conditions have an assortment of hazard factors that impact oral well-being. This work was conducted to study the prevalence of dental caries, body mass index (BMI), and socioeconomic status (SES) among preschoolers in private preschools and Anganwadi centers within Bengaluru.

A survey of vocal health in church choir singers.

Purpose: Choir singing is an important tradition of Christian worship across India. However, vocal health issues related to the church choir singers are less addressed in the literature. Hence, this study aimed to investigate the prevalence of vocal symptoms, identify the variables associated with increased risk of voice problems and knowledge of factors influencing vocal health in church choir singers.

Data-driven modelling and prediction of COVID-19 infection in India and correlation analysis of the virus transmission with socio-economic factors.

Aims: The current study attempts to model the COVID-19 outbreak in India, USA, China, Japan, Italy, Iran, Canada and Germany. The interactions of coronavirus transmission with socio-economic factors in India using the multivariate approach were also investigated.

Methods: Actual cumulative infected population data from 15 February to May 15, 2020 was used for determination of parameters of a nested exponential statistical model, which were further employed for the prediction of infection.

Comparative analysis of ChIP-exo peak-callers: impact of data quality, read duplication and binding subtypes.

Background: ChIP (Chromatin immunoprecipitation)-exo has emerged as an important and versatile improvement over conventional ChIP-seq as it reduces the level of noise, maps the transcription factor (TF) binding location in a very precise manner, upto single base-pair resolution, and enables binding mode prediction. Availability of numerous peak-callers for analyzing ChIP-exo reads has motivated the need to assess their performance and report which tool executes reasonably well for the task.

Results: This study has focussed on comparing peak-callers that report direct binding events with those that report indirect binding events.