Antisense and Functional Nucleic Acids in Rational Drug Development.

This review is focused on antisense and functional nucleic acid used for completely rational drug design and drug target assessment, aiming to reduce the time and money spent and increase the successful rate of drug development. Nucleic acids have unique properties that play two essential roles in drug development as drug targets and as drugs. Drug targets can be messenger, ribosomal, non-coding RNAs, ribozymes, riboswitches, and other RNAs.

Effect of Cu as a Minority Alloying Element on the Corrosion Behaviour of Amorphous and Crystalline Al-Ni-Si Alloy.

The effect of copper as a minority alloying element on the corrosion behaviour of amorphous and crystalline AlNiSi and AlNiSiCu alloys was investigated in this study. Amorphous alloys were produced as rapidly solidified ribbons using the Chill Block Melt Spinning (CBMS) method and subsequently annealed to complete crystallisation. The corrosion rate of alloys was obtained through continuous immersion tests in 3.