The Risk of Breakthrough Cardiac Events Associated With Psychiatric Medications in Patients With Diagnosed and Clinically Treated Long QT Syndrome.

Background: Long QT syndrome (LQTS) is a potentially life-threatening genetic heart disease. Because many psychiatric medications have QT-prolonging potential, there is hesitation when prescribing them to LQTS patients with concomitant psychiatric disorders, which may lead to suboptimal mental health care.

Objectives: This study sought to evaluate the incidence of breakthrough cardiac events (BCEs) in patients with diagnosed and clinically treated LQTS on QT-prolonging psychiatric medications.

Enhancement of the Mayo Clinic HCM Genotype Predictor Score with Addition of Cardiac Magnetic Resonance Imaging.

This study aimed to evaluate the role of cardiac magnetic resonance (CMR) in updating The Mayo Clinic Hypertrophic Cardiomyopathy (HCM) Genotype Predictor Score. We performed an analysis of 175 HCM patients with an echocardiogram, CMR, and genetic test at the Mayo Clinic (2004 to 2018). Yield of a positive genetic test for the original echocardiogram-based score ranged from 38% (-1 point) to 100% (4 or 5 points), with an AUC of 0.

The clinical and electrocardiographic phenotype of patients with genotype-negative long QT syndrome.

Background: Long QT syndrome (LQTS) is a genetic heart disease that increases the risk of ventricular arrhythmias and sudden cardia arrest. Despite advances in genetic testing, a small subset of patients with LQTS remain genetically elusive.

Objective: This study aimed to determine the prevalence and clinical characteristics of patients with a phenotype of LQTS but without a genotype.

Continuation Versus Interruption of Oral Anticoagulation During TAVI: A Systematic Review and Meta-Analysis Oral Anticoagulation Management in TAVI.

Patients undergoing transcatheter aortic valve implantation (TAVI) often require long-term oral anticoagulation (OAC), but it is unclear whether to continue or interrupt OAC during the procedure. This meta-analysis compares clinical outcomes of continuing versus interrupting OAC during TAVI. PubMed, Embase, and Cochrane Central databases were searched from inception to September 2024 for studies comparing continuation versus interruption of OAC in patients undergoing TAVI with an indication for OAC, including vitamin K antagonists and direct oral anticoagulants.

Combined Heart and Liver Transplantation in the Failing Fontan: Systematic Review and Single-arm Meta-analysis.

Background: The Fontan procedure has transformed the management of congenital heart defects characterized by single ventricle physiology, yet it predisposes individuals to Fontan-associated liver disease. Combined heart and liver transplantation (CHLT) emerges as a therapeutic option, but evidence of its efficacy and safety remains limited. This study aimed to comprehensively evaluate CHLT in Fontan patients, focusing on patient characteristics, perioperative outcomes, and posttransplant morbidity and mortality.

Echocardiographic Diagnosis of Hypertrophic Cardiomyopathy by Machine Learning.

Objective: To develop machine learning tools for automated hypertrophic cardiomyopathy (HCM) case recognition from echocardiographic metrics, aiming to identify HCM from standard echocardiographic data with high performance.

Patients And Methods: Four different random forest machine learning models were developed using a case-control cohort composed of 5548 patients with HCM and 16,973 controls without HCM, from January 1, 2004, to March 15, 2019. Each patient with HCM was matched to 3 controls by sex, age, and year of echocardiography.

Epicardial substrate ablation in patients with symptomatic Brugada syndrome: an updated systematic review and single-arm meta-analysis.

Background: Brugada syndrome (BrS) is a genetic heart disease that predisposes individuals to ventricular arrhythmias and sudden cardiac death. Although implantable cardioverter-defibrillators (ICDs) and quinidine are primary treatments, recurrent BrS-triggered ventricular arrhythmias can persist. In this setting, epicardial substrate ablation has emerged as a promising alternative for symptomatic patients.

Levetiracetam versus carbamazepine monotherapy in the management of pediatric focal epilepsy: A systematic review and meta-analysis of randomized controlled trials.

Levetiracetam (LEV) and carbamazepine (CBZ) are effective monotherapies for focal epilepsy in children. However, the best drug remains controversial. Therefore, we performed a systematic review and meta-analysis comparing LEV and CBZ monotherapy in the management of pediatric focal epilepsy (PFE).

Effects of colchicine on the prevention of AF recurrence after atrial ablation: a systematic review and meta-analysis.

Background: Catheter ablation has become a widely accepted treatment for atrial fibrillation, but early recurrences remain a challenge, often attributed to inflammatory responses triggered during the procedure. This systematic review and meta-analysis aimed to evaluate the effectiveness of colchicine in preventing short-term AF recurrence post-ablation.

Method: PubMed, Embase, and Cochrane Library were searched for studies comparing use of colchicine and placebo in patients after AF ablation.

Early versus Late Caffeine Therapy Administration in Preterm Neonates: An Updated Systematic Review and Meta-Analysis.

Background: Caffeine is commonly used as therapy for apnea of prematurity and has shown potential in preventing other conditions in preterm neonates. However, the optimal timing for caffeine therapy remains uncertain.

Objective: This study aimed to compare the outcomes of early versus late administration of caffeine in preterm neonates.