Publications by authors named "Van-Dat Truong"
Article Synopsis
- The text refers to a correction made to an article with the DOI 10.3389/fphar.2023.1156655.
- This correction likely addresses inaccuracies or updates in the original publication.
- The article is published in a pharmacology journal, suggesting it focuses on a topic related to pharmaceuticals or drug research.
Antimalarial activities of benzothiazole analogs: A systematic review.
Fundam Clin Pharmacol
June 2024
Background: Benzothiazole derivatives have been reported to possess a wide range of biological activities, including antimalarial activity. This systematic review aims to summarize and evaluate the antimalarial activities of benzothiazole analogs.
Methods: We conducted an electronic search using nine databases in October 2017 and subsequently updated in September 2022.
Article Synopsis
- Vietnam aimed for "Zero-COVID" but faced a major outbreak due to the Delta variant, especially in Ho Chi Minh City, prompting a study on public knowledge and behaviors regarding COVID-19.
- A survey conducted with 963 residents revealed that medical staff had better KAPP scores compared to non-medical individuals, indicating varying levels of awareness and practices in the community.
- The study highlighted strong correlations between knowledge, attitude, perception, and practice, emphasizing that improving citizens' understanding and behaviors is essential for effective pandemic management alongside government efforts.
The coronavirus disease 2019 (COVID-19) pandemic has caused a lot of ethical controversy in the equal provision of healthcare, including vaccination. Therefore, our study was designed to assess the impact of Ho Chi Minh City's policy to hold the second dose of the COVID-19 vaccine. Using a cross-sectional study design to assess low saturation of peripheral oxygen (SPO2) risk based on vaccination status, we included patients who were confirmed to have SARS-CoV-2 and were treated at home.
View Article and Find Full Text PDFBackground: Emergence of cross-resistance to current anti-malarial drugs has led to an urgent need for identification of potential compounds with novel modes of action and anti-malarial activity against the resistant strains. One of the most promising therapeutic targets of anti-malarial agents related to food vacuole of malaria parasite is haemozoin, a product formed by the parasite through haemoglobin degradation.
Methods: With this in mind, this study developed two-dimensional-quantitative structure-activity relationships (QSAR) models of a series of 21 haemozoin inhibitors to explore the useful physicochemical parameters of the active compounds for estimation of anti-malarial activities.
Background: Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection. Haemozoin is considered as a novel inhibitory pathway for new anti-malarial drugs, therefore, this study aimed to systematically review all articles investigating the correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds.
Methods: A literature search was conducted on 22 October 2017 in eight databases for relevant in vitro articles reporting the correlation between anti-malarial and anti-haemozoin of anti-malarial compounds, based on the constructed search terms and inclusion criteria.
Chemically diverse heterocyclic chalcones were prepared and evaluated for cytotoxicity, aiming to push forward potency and selectivity. They were tested against rhabdomyosarcoma (RMS) and noncancerous cell line (LLC-PK1). The influence of heteroaryl patterns on rings A and B was studied.
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