An Analysis of Diagnostic Metabolomic Profiles Associated with Hepatotoxicity During Childhood ALL Induction Therapy.

Hepatotoxicity is a well-documented complication of induction chemotherapy for acute lymphoblastic leukemia (ALL), but our understanding of the biological mechanisms is limited. We identified 314 patients with ALL (age 1-19 years) treated at Texas Children's Hospital (2007-2018) with diagnostic bone marrow plasma available for metabolomic profiling: 234 for discovery and 80 for replication. Hepatotoxicity during induction therapy was defined as: 1) transaminitis: grade ≥3 AST or ALT, or 2) conjugated hyperbilirubinemia: conjugated bilirubin (c.

Capillary assembly of metal-coated polymer microspheres for interconnection in electronic applications.

Interconnection technologies utilizing metal-coated polymer microspheres (MPS) offer promising solutions for applications with fine-pitch, high-density interconnects. The capability of controlling the position and number of MPS in individual interconnects is considered key to further realizing these technologies in emerging applications where large dies with an extremely high number of ultra-fine pitch input/output pins and/or temperature-sensitive substrates are often involved. This study introduces an innovative approach for the deposition of MPS, ranging from 4.

Prediction of methotrexate neurotoxicity using clinical, sociodemographic, and area-based information in children with acute lymphoblastic leukemia.

Background: Methotrexate is a critical component of pediatric acute lymphoblastic leukemia (ALL) therapy that can result in neurotoxicity which has been associated with an increased risk of relapse. We leveraged machine learning to develop a neurotoxicity risk prediction model in a diverse cohort of children with ALL.

Methods: We included children (age 2-20 years) diagnosed with ALL (2005-2019) and treated in Texas without pre-existing neurologic disease.

Comparison between self-reported and pedometer-measured physical activity in Vietnamese adolescents: A reliability and agreement study.

To compare the level of physical activity (PA) measured by self-reported questionnaire and pedometer in 12-year-old Vietnamese adolescents. Data was collected from March to May 2023 in two phases among 510 sixth-grade students in Ho Chi Minh City, Vietnam. The first phase involved a pilot study, which recruited 35 students from a randomly selected class to evaluate the Physical Activity Questionnaire for Older Children (PAQ-C) test-retest reliability.

Robust super-twisting algorithm-based single-phase sliding mode frequency controller in power systems integrating wind turbines and energy storage systems.

Frequency regulation in multi-area power systems (MPSs) faces increasing challenges due to the integration of renewable energy sources, such as wind power, and the dynamic behavior of energy storage systems (ESSs). These challenges are further compounded by disturbances from tie-line power exchanges, wind power fluctuations, and variations in battery and flywheel storage. To address this, this paper proposes a robust sliding mode control (SMC) strategy based on a proportional-derivative sliding surface (PD-SS) structure for load frequency control (LFC), leveraging a single-phase approach enhanced by an improved super-twisting algorithm (ISTA).

Correction: Alterations in aortic elasticity indices among type 2 diabetes patients in a low and middle income country using M-mode echocardiography: A cross-sectional comparative study.

[This corrects the article DOI: 10.1371/journal.pone.

Evaluation of methotrexate Pharmacogenomic variation to predict acute neurotoxicity in children with acute lymphoblastic leukemia.

Background: Methotrexate is an important component of curative therapy in childhood acute lymphoblastic leukemia (ALL), but the role of genetic variation influencing methotrexate clearance and transport in toxicity susceptibility in children with ALL is not well established. Therefore, we evaluated the association between suspected methotrexate pharmacogenomic variants and methotrexate-related neurotoxicity.

Methods: This study included children (aged 2-20 years) diagnosed with ALL (2005-2019) at six treatment centers in the southwest United States.

Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021.

COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.

Role of dietary potassium and salt substitution in the prevention and management of hypertension.

Cardiovascular diseases (CVD) continue to be the leading cause of deaths and disability worldwide and the major contributor is hypertension. Despite all the improvements in detecting hypertension together with technological advances and affordable, efficacious and relatively free of adverse effects anti-hypertensive agents, we continue to struggle to prevent the onset of hypertension and to control blood pressure (BP) to acceptable targets. The poor control of hypertension is commonly due to non-adherence to medications.

Compliant Interconnects Based on Single Micrometer-sized Metal-Coated Polymer Spheres.

The rapid evolution of multifunctional electronics necessitates interconnection technologies appropriate for large dies with high-density and/or ultrafine pitch input/output pins. Existing technologies face numerous challenges, including demands for bonding equipment that can deliver extremely high force as well as thermo-mechanical stresses induced in the assembled packages due to mismatched thermal expansion of materials involved. This study proposes an approach to compliant interconnects comprising single micrometer-sized metal-coated polymer spheres, being joined to mating electrodes by sintering of Ag nano ink at low temperature (140 °C) and low pressure (∼15 mN/particle).

Alterations in aortic elasticity indices among type 2 diabetes patients in a low and middle income country using M-mode echocardiography: A cross-sectional comparative study.

Background: Diabetes is one of the leading causes of noncommunicable diseases worldwide. It is known to induce cardiovascular remodeling, which can result in a variety of complications, including a considerable increase in aortic stiffness. While studies in Western populations have explored these effects, data on Asians, mainly Vietnamese, are limited.

Reducing learning and psychosocial disparities in Latino children with cancer: a randomized intervention trial.

Background: We developed a high-intensity parenting intervention program (HIP) to help parents support the academic success of childhood cancer survivors (CCSs), who often face post-treatment challenges affecting their school-related functioning. This randomized controlled trial (NCT03178617) evaluated HIP's efficacy compared with lower-intensity, single-session, treatment-as-usual services (lower-intensity program [LIP]) in Latino families. Primary outcomes were parenting efficacy and CCSs' school functioning; secondary outcomes included parenting knowledge and measures of CCSs' academic performance, attention, and functioning outside of school.

3D-printed porous titanium suture anchor: a rabbit lateral femoral condyle model.

Background: The inclusion of a connecting path in a porous implant can promote nutrient diffusion to cells and enhance bone ingrowth. Consequently, this study aimed to evaluate the biomechanical, radiographic, and histopathological performance of a novel 3D-printed porous suture anchor in a rabbit femur model.

Methods: Three test groups were formed based on the type of suture anchor (SA): Commercial SA (CSA, Group A, n = 20), custom solid SA (CSSA, Group B, n = 20), and custom porous SA (CPSA, Group C, n = 20).

Adaptive response of under serial ciprofloxacin exposure.

Understanding the evolution of antibiotic resistance is important for combating drug-resistant bacteria. In this work, we investigated the adaptive response of to ciprofloxacin. Ciprofloxacin-susceptible ATCC 9027, CIP-E1 ( ATCC 9027 exposed to ciprofloxacin for 14 days) and CIP-E2 (CIP-E1 cultured in antibiotic-free broth for 10 days) were compared.

Photoinduced charge generation of nanostructured carbon derived from human hair biowaste for performance enhancement in polyvinylidene fluoride based triboelectric nanogenerator.

Carbon nanostructures derived from human hair biowaste are incorporated into polyvinylidene fluoride (PVDF) polymer to enhance the energy conversion performance of a triboelectric nanogenerator (TENG). The PVDF filled with activated carbon nanomaterial from human hair (AC-HH) exhibits improved surface charge density and photoinduced charge generation. These remarkable properties are attributed to the presence of graphene-like nanostructures in AC-HH, contributing to the augmented performance of PVDF@AC-HH TENG.

[Antenatal care for fetuses with congenital diaphragmatic hernia].

Congenital diaphragmatic hernia (CDH) can be diagnosed prenatally and its severity assessed by fetal imaging. The prognosis of a fetus with CDH is based on whether or not the hernia is isolated, the measurement of lung volume on ultrasound and MRI, and the position of the liver. The birth of a child with CDH should take place in a center adapted to the care of such children, and in accordance with the recommendations defined by the French National Diagnosis and Care Protocol.

Oculo-facio-cardio-dental (OFCD) syndrome: a case report.

Background: Oculo-facio-cardio-dental (OFCD) syndrome is a rare condition that affects the eyes, face, heart, and teeth of patients. One notable dental characteristic of OFCD is radiculomegaly, or root gigantism, which highlights the role of dentists in detecting this syndrome. OFCD is an X-linked dominant syndrome that results from a variant in the BCOR gene.

Application of cluster repeated mini-batch training method to classify electroencephalography for grab and lift tasks.

Modern deep neural network training is based on mini-batch stochastic gradient optimization. While using extensive mini-batches improves the computational parallelism, the small batch training proved that it delivers improved generalization performance and allows a significantly smaller memory, which might also improve machine throughput. However, mini-batch size and characteristics, a key factor for training deep neural networks, has not been sufficiently investigated in training correlated group features and looping with highly complex ones.

Professional quality of life and its associated factors among Vietnamese doctors and nurses.

Background: Prevalence of health workers with occupational health issues ranked fourth among all careers resulting in a reduction in quality of life. However, tools to measure professional quality of life (ProQoL) are unavailable in Vietnamese. This study aims to develop a Vietnamese version of the ProQoL, and examine ProQoL and its associated factors among doctors and nurses.

Home blood pressure-centered approach - from digital health to medical practice: HOPE Asia Network consensus statement 2023.

Recent innovations in digital technology have enabled the simultaneous accumulation, and the linking and analysis of time-series big data relating to several factors that influence blood pressure (BP), including biological indicators, physical activity, and environmental information. Various approaches can be used to monitor BP: in the office/clinic; at home; 24-h ambulatory recording; or with wearable and cuffless devices. Of these, home BP monitoring is a reliable and convenient method, and is recommended for hypertension management by current national and international guidelines.

Validation of Point-of-Care Device for Rapid Detection of in Meat Products.

Accurate and rapid detection of pathogens in foods of animal origin has been a critical part of the One Health Action Plan of the European Union (EU). Biosensors have the potential in bringing required technologies to accomplish this on the field, wherein loop-mediated isothermal amplification (LAMP) and lab-on-a-chip have proven to be ideal. We have developed a LAMP-based point-of-care (POC) device, the VETPOD, as a solution to the contemporary challenges in the rapid detection of spp.

Ultrasound-Assisted Lipid Extraction from Chlorella sp.: Taguchi Design and Life Cycle Assessment.

The present study delved into the enhancement of essential oil (EO) extraction process from Chlorella sp. through the implementation of ultrasound-assisted extraction. The Taguchi method was instrumental in determining the ideal parameters for the extraction process, which encompassed ultrasonic amplitude, reaction duration, hexane/ethanol (HE/EtOH) ratio, and processing temperature.

Clinical and radiological characteristics of odontomas: A retrospective study of 90 cases.

Purpose: Odontomas represent a common clinical entity among odontogenic tumors, but are not well-addressed in the Vietnamese population. The present study aimed to determine the clinical and preclinical characteristics of odontomas and associated factors in the Vietnamese population.

Materials And Methods: This retrospective study retrieved data from histopathological diagnoses from 2 central hospitals of Odonto-Stomatology in Ho Chi Minh City, Vietnam during 2004-2017.