Publications by authors named "Vahin Patel"
Introduction: Immunotherapy has transformed cancer treatment, particularly with immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy. Despite their efficacy, these therapies can induce cardiotoxicity, presenting significant clinical challenges. Immune checkpoint inhibitors can cause myocarditis; pericarditis; arrhythmias; and myocardial infarction through immune-mediated inflammation.
View Article and Find Full Text PDFIn addition to traditional risk factors, patients with breast cancer are at an increased risk of atrial fibrillation due to cancer itself and certain cancer therapies. Atrial fibrillation in these patients adds to their morbidity and mortality. The precise mechanisms leading to the increased atrial fibrillation in patients with breast cancer are not well understood.
View Article and Find Full Text PDFBackground: Guidelines recommend palliative care (PC) for patients with heart failure. However, little research has been performed assessing the effect of PC consultation in patients with heart failure with preserved ejection fraction (HFpEF).
Objectives: The purpose of this study was to investigate the impact of PC consultation on symptom burden and health care utilization among individuals with HFpEF during the last 3 years of their lives.
Article Synopsis
- - Immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy have drastically improved cancer treatment but can lead to serious cardiovascular issues, notably myocarditis.
- - Diagnosis of ICI-myocarditis involves using a combination of biomarkers, imaging, and endomyocardial biopsy, while cytokine release syndrome (CRS) presents similar symptoms to distributive shock.
- - Effective management includes stopping the offending therapy, providing immunosuppression with corticosteroids for ICI-myocarditis, and using interleukin-6 antagonists for CRS, requiring close collaboration between oncologists and cardiologists for optimal care.
Background: Although diuretic-induced Acute Pancreatitis (AP) cases are typically mild to moderate, severe and potentially fatal occurrences can arise. Case Series and Literature Review: We have, herein, presented a series of diuretic-induced AP cases from March 2018 to February 2024 of a 54-year-old woman treated with chlorthalidone, a 45-year-old male treated with hydrochlorothiazide, and a 48-year-old male treated with frusemide. The literature search has identified 26 cases published to date, 10 from frusemide and 16 from thiazide diuretics.
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