Sexual health is a critical component of quality of life. Chronic pain can significantly impair sexual functioning through complex and multimodal effects spanning physical, psychological, and social domains. Nevertheless, when properly managed, many people with chronic pain can still enjoy fulfilling sexual relationships.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
April 2025
Diversification of plant hydraulic architecture and stomatal function coincides with radical changes in the Earth's atmosphere over the past 400 my. Due to shared stomatal anatomy with the earliest land plants, bryophyte stomatal behavior may provide insights into the evolution of stomatal function, but significant uncertainty remains due to technical limitations of measuring guard cell turgor pressure in situ. Here, we introduce a method for monitoring cell turgor pressure by nucleating microbubbles within the guard cells of intact plant tissue and then examining microbubble growth and dissolution dynamics.
View Article and Find Full Text PDFDry season droughts may increasingly threaten Mediterranean forests under climate change. While plants employ three desiccation avoidance strategies to avoid or delay dehydration damage, including reduced water loss, enhanced tissue water storage, and improved root water access, resource allocation competition may lead to trade-offs among these strategies that are not yet fully understood. We investigated six Mediterranean woody species by analysing: (1) twig hydraulic capacitance (0.
View Article and Find Full Text PDFDrought stress reduces leaf net assimilation (A) and phloem export, but the equilibrium between the two is unknown. Consequently, the leaf carbon balance and the primary use of the leaf nonstructural carbohydrates (NSC) under water deficit are unclear. Also, we do not know how quickly leaves can replenish their NSC storage and resume export after rehydration.
View Article and Find Full Text PDFBackground And Aims: Nolana mollis is a dominant plant species in the hyper-arid Atacama Desert. A previous hypothesis states that N. mollis owes its success to the condensation of atmospheric water from undersaturated air onto its leaf surfaces by exuded salts, and absorption of this water by its leaves, or by shallow roots following drip onto the soil surface; living roots of N.
View Article and Find Full Text PDFUnderstanding the relationship between wind speed and gas exchange in plants is a longstanding challenge. Our aim was to investigate the impact of wind speed on maximum rates of gas exchange and the kinetics of stomatal responses. We conducted experiments in different angiosperm and fern species using an infrared gas analyzer equipped with a controlled leaf fan, enabling precise control of the boundary layer conductance.
View Article and Find Full Text PDFIn ecophysiology leaves are frequently stored for hours after sampling before measuring their leaf water potential (Ψ). Here, we address a previously unidentified source of error, that metabolic heat generation can cause continuous water loss from leaves stored in impermeable bags, leading to a Ψ drop over time. We tested Ψ drop rates under various conditions: two bag materials, two species, initial Ψ above or below the turgor loss point (Ψ), and storage at 25°C versus 4°C.
View Article and Find Full Text PDFBackground And Aims: Each branch internode, with the organs growing on it, can be seen as a single morphological phytomer subunit made of structurally and functionally interrelated components. However, allometric relationships between the anatomy and morphology of these subunits remain unclear, particularly in the axial context. The aim of this study was to address this knowledge gap by measuring morpho-anatomical parameters and their allometric relationships along grapevine shoots.
View Article and Find Full Text PDFBMC Palliat Care
July 2024
Purpose: Neurosurgical ablative procedures, such as cordotomy and cingulotomy, are often considered irreversible and destructive but can provide an effective and individualized solution for cancer-related refractory pain, when all other approaches have been unsuccessful. This paper provides an in-depth exploration of a novel approach to managing refractory cancer pain. It involves an interdisciplinary team led by a neurosurgeon at a renowned national referral center.
View Article and Find Full Text PDFThis article comments on: Gabriela Sinclair, Erin R. Galarneau, Josh F. Hnizdor, Andrew J.
View Article and Find Full Text PDFPlant Physiol Biochem
March 2024
Plants require potassium (K) to support growth and regulate hydraulics. Yet, K's effects on transpiration are still speculated. We hypothesized that K deficiency would limit grapevine water uptake by limiting canopy size and stomatal conductance (g).
View Article and Find Full Text PDFBMJ Support Palliat Care
August 2024
Background And Objectives: Cancer-related pain management in advanced stages presents a significant challenge that often requires a multidisciplinary approach. Although advancements in pharmacological and interventional therapies, a considerable number of patients still suffer from refractory pain, leading to unmet clinical needs. This study shares our experience with medical cannabis (MC) as a potential therapy for this specific population of patients with cancer-related refractory pain.
View Article and Find Full Text PDFRecent findings suggest that trees can survive high levels of drought-induced xylem embolism. In many cases, the embolism is irreversible and, therefore, can potentially affect post-drought recovery and tree function under recurring droughts. We examined the development of embolism in potted Aleppo pines, a common species in hot, dry Mediterranean habitats.
View Article and Find Full Text PDFBackground And Objectives: Cordotomy, the selective disconnection of the nociceptive fibers in the spinothalamic tract, is used to provide pain palliation to oncological patients suffering from intractable cancer-related pain. Cordotomies are commonly performed using a cervical (C1-2) percutaneous approach under imaging guidance and require patients' cooperation to functionally localize the spinothalamic tract. This can be challenging in patients suffering from extreme pain.
View Article and Find Full Text PDFClimate change presents a challenge for plants to acclimate their water relations under changing environmental conditions, and may increase the risks of hydraulic failure under stress. In this study, maize plants were acclimated to two different CO2 concentrations ([CO2]; 400 ppm and 700 ppm) while under either water stress (WS) or soil salinity (SS) treatments, and their growth and hydraulic traits were examined in detail. Both WS and SS inhibited growth and had significant impacts on hydraulic traits.
View Article and Find Full Text PDFJ Exp Bot
November 2023
Under most conditions tight stomatal regulation in grapevines (Vitis vinifera) avoids xylem embolism. The current study evaluated grapevine responses to challenging scenarios that might lead to leaf embolism and consequential leaf damage. We hypothesized that embolism would occur if the vines experienced low xylem water potential (Ψx) shortly after bud break or later in the season under a combination of extreme drought and heat.
View Article and Find Full Text PDFPurpose: Minimally invasive lumbar decompression (MIS) in obese pzatients is technically challenging due to the use of longer tube retractors. The purpose of this study was to evaluate the impact of the thickness of the soft tissue and subcutaneous fat on complications, revisions, and patient-reported functional outcomes after MIS.
Methods: This is a retrospective analysis of 148 consecutive patients who underwent minimally invasive lumbar decompression at our institute between 2013 and 2017 and had at least one year of follow-up.
Background: Tobacco smoking is a major cause of morbidity and mortality worldwide. Several authors reported a significant negative impact of smoking on the outcome of spinal surgeries. However, comparative studies on the effect of smoking on the outcome of minimally invasive (MIS) spinal decompression are rare with conflicting results.
View Article and Find Full Text PDFPurpose: While advanced medical technology and unlimited access to medical information might benefit and empower patients, these same advantages may pose some risks, especially in the cases where patients have direct access to advanced imaging studies. The aim of this work was to evaluate three domains related to patients with lower back pain: the patients' perceptions, misconceptions and the experience of anxiety-related symptoms following direct access to their thoraco-lumbar spine radiology report. An additional aim was the assessment of possible associations with catastrophization.
View Article and Find Full Text PDFPlant Cell Environ
June 2023
Cavitation resistance has often been viewed as a relatively static trait, especially for stems of forest trees. Meanwhile, other hydraulic traits, such as turgor loss point (Ψ ) and xylem anatomy, change during the season. In this study, we hypothesized that cavitation resistance is also dynamic, changing in coordination with Ψ .
View Article and Find Full Text PDFHuman pain is a salient stimulus composed of two main components: a sensory/somatic component, carrying peripheral nociceptive sensation via the spinothalamic tract and brainstem nuclei to the thalamus and then to sensory cortical regions, and an affective (suffering) component, where information from central thalamic nuclei is carried to the anterior insula, dorsal anterior cingulate cortex and other regions. While the sensory component processes information about stimulus location and intensity, the affective component processes information regarding pain-related expectations, motivation to reduce pain and pain unpleasantness. Unlike investigations of acute pain that are based on the introduction of real-time stimulus during brain recordings, chronic pain investigations are usually based on longitudinal and case-control studies, which are limited in their ability to infer the functional network topology of chronic pain.
View Article and Find Full Text PDFBackground: Cauda Equina syndrome (CES) is a potentially devastating condition and is treated usually with urgent open surgical decompression of the spinal canal. Currently, the role of minimally invasive discectomy (MID) as an alternative surgical technique for CES is unclear.
Objective: The purpose of this study was to compare clinical outcomes following MID and open laminectomy and discectomy for the treatment of CES.
The hydraulic system of vascular plants and its integrity is essential for plant survival. To transport water under tension, the walls of xylem conduits must approximate rigid pipes. Against this expectation, conduit deformation has been reported in the leaves of a few species and hypothesized to function as a 'circuit breaker' against embolism.
View Article and Find Full Text PDFPain Res Manag
October 2022
Background: Chronic pain (CP) prevalence in different studies has been inconsistent, ranging from 12% in Spain to 42% in the UK.
Purpose: We conducted an internet-based survey in a representative cohort of Israeli adults assembled by a large professional survey company in order to probe the prevalence of CP in Israel.
Methods: 8,300 Israeli adults comprising a representative cohort of the Israeli population were asked whether they were suffering from pain lasting over 3 months.