Sprayable ciprofloxacin loaded chitosan nanospheres-based topical formulation for eliminating multidrug-resistant bacteria and accelerating infected wound healing.

Multidrug-resistant (MDR) bacteria represent a formidable global health crisis with a substantial risk of prolonged infections due to the diminishing efficacy of traditional antibiotic therapies against these resilient pathogens. A dual strategy offering rapid inactivation of MDR bacteria and reduction in wound area could effectively promote wound healing. In this work, we developed a sprayable topical formulation by integrating a biocompatible biopolymer chitosan with a chemotherapeutic drug ciprofloxacin.