Alpha-Glucosidase and Nitric Oxide Inhibitors from Paramignya trimera Leaves and Dicranopteris linearis Spores: In Silico and In Vitro Aspects.

Dicranopteris linearis and Paramignya trimera, widely utilized plants in traditional Vietnamese medicine, lack comprehensive chemical and biological data pertaining to their composition. The crude extracts of these biosources showed remarkable alpha-glucosidase and nitric oxide (NO) inhibition. Bioguided isolation based on alpha-glucosidase inhibition and anti-inflammatory activity was applied to P.

Triterpenoids from leaves of with their alpha-glucosidase inhibition: and aspects.

From the leaves of , a new C-noreuphane-type triterpenoid, paramignyene (), together with four known triterpenoids, kansenone (), eupha-8,25-diene-3,24-diol-7-one (), eupha-7,25-diene-3,24-diol (), and -sitosterol (), were isolated and structurally elucidated. Paramignyene () represents the first C-noreuphane-type triterpenoid in nature. Their chemical structures were established using comprehensive spectroscopic data (1D- and 2D-NMR and HRESIMS).

Bio-guided isolation of alpha-glucosidase inhibitory compounds from Vietnamese fruits: and studies.

is an edible tree widely distributed in the southern region of Vietnam. Little is known about the alpha-glucosidase inhibition of the Vietnamese . The aim of the current study was to explore the anti-diabetic potential of fruits.

Tecomastane, a new megastigmane from the flowers of .

is a tropical plant that is widely used in folk medicine. Little is known about the chemical constituents of flowers of this plant. From flowers of the native plant in Vietnam, 12 compounds were isolated and elucidated, including one new compound tecomastane () and eleven known compounds, (3,5,6,7)-5,6-epoxy-3-hydroxy-7-megastigmane-9-one (), bosciallin (), chakyunglupulin B (), (2,6)-2,6-dimethyloctane-1,8-diol (), cleroindicin F (), rengyoxide (), 3,4-dihydroxybenzoic acid (), methyl 3,4-dihydrobenzoate (), 3,5-dihydroxybenzoic acid (), luteolin (), and indole-3-carboxylic acid ().

Injury prevalence and safety habits of boda boda drivers in Moshi, Tanzania: A mixed methods study.

Background: Traffic crashes are a major cause of global morbidity and mortality disproportionately affecting low- and middle-income countries (LMICs). Motorcycle taxi (boda boda) drivers are particularly vulnerable because they are exposed to traffic risks with limited safety equipment. This study aims to characterize injury prevalence and safety habits among boda boda drivers, as well as ways to improve road traffic safety in LMICs.