Triterpenoids from leaves of with their alpha-glucosidase inhibition: and aspects.

From the leaves of , a new C-noreuphane-type triterpenoid, paramignyene (), together with four known triterpenoids, kansenone (), eupha-8,25-diene-3,24-diol-7-one (), eupha-7,25-diene-3,24-diol (), and -sitosterol (), were isolated and structurally elucidated. Paramignyene () represents the first C-noreuphane-type triterpenoid in nature. Their chemical structures were established using comprehensive spectroscopic data (1D- and 2D-NMR and HRESIMS). All isolated compounds were evaluated for their alpha-glucosidase inhibition. Only compounds and exhibited moderate activity, with IC values of 86 and 220 µM, respectively. Molecular docking analysis elucidates the inhibitory mechanism of the tested compounds. Compounds - were evaluated for cytotoxicity against the HepG2 and Hek293 cell lines. Compound exhibited moderate cytotoxic activity against HepG2, while the other compounds demonstrated no cytotoxic activity. Furthermore, none of the compounds demonstrated any activity against normal cell line Hek293.