Impact of pump position on postoperative outcomes in less invasive left ventricular assist device implantation.

Introduction: less invasive approach (LIS) has recently become increasingly used for left ventricular assist device (LVAD) implantation. However, the impact of surgical access on pump position and clinical outcomes comparing LIS-LVAD implantation to full sternotomy (ST) has not been well discussed.

Methods: Between April 2010 and February 2021, a total of 237 consecutive patients received a LVAD, 76 (32.

Comparison of Clinical and Radiographic Outcomes Following Early Anterior Cruciate Ligament Reconstruction Versus Delayed Reconstruction for Skeletally Immature Patients Using a Physeal-Sparing Anatomical Double-Bundle Reconstruction Technique.

Purpose In anterior cruciate ligament (ACL) injury among young patients, non-operative treatments are the common approach. However, meniscal and cartilage damage have been associated with this treatment, highlighting the need to explore surgical procedures for treating pediatric ACL injuries. We employed a modification of the hybrid physeal-sparing and anatomical double-bundle ACL reconstruction (ACLR) in skeletally immature patients.

Evaluating outcomes of revision anterior cruciate ligament reconstruction with rectangular tunnel technique using a bone-patellar tendon-bone graft: A propensity score matching analysis indicating comparable results to primary reconstruction.

Purpose: This study aimed to investigate whether one-stage revision anterior cruciate ligament reconstruction (ACLR) using the rectangular tunnel (RT) technique with a bone-tendon-bone (BTB) graft can achieve outcomes comparable to primary ACLR. It was hypothesized that both one-stage revision and primary ACLR using the RT technique with a BTB graft would provide comparable clinical outcomes.

Methods: We enroled 935 patients who underwent primary or revision ACLR by a single surgeon between 2012 and 2022.

Iatrogenic aortic dissection in minimally invasive cardiac surgery for atrioventricular valves and atrial structures†.

Objectives: In the last decades, minimally invasive cardiac surgery has emerged as an alternative approach to conventional median sternotomy. However, some reports state an increased risk of iatrogenic acute aortic dissection. Evidence remains limited regarding preoperative diagnostics for risk reduction and the appropriate adjustment of surgical procedures if acute aortic dissection is detected intraoperatively.

Health and economic impact of 20-valent pneumococcal conjugate vaccine for adults aged 66-84 years in Japan and Shiga prefecture.

Background: The Japanese National Immunization Program against pneumococcal disease (PD) includes 23-valent pneumococcal polysaccharide vaccine (PPSV23) but does not provide vaccination for adults aged ≥66 years. We evaluated the cost-effectiveness of 20-valent pneumococcal conjugate vaccine (PCV20) in adults aged 66-84 years with no history of PPSV23 vaccination in Japan and assessed the potential economic and health impact of introducing PCV20 on the local government (specifically, Shiga prefecture).

Research Design And Methods: Using a Markov model, we assessed lifetime costs, quality-adjusted life-years (QALYs), and number of prevented cases and deaths caused by PD.

Methane emission prediction models for lactating cows based on feed intake, body weight, and milk yield and composition: Variable methane conversion factor-based approach.

The first objective of this study was to develop CH emission prediction models based on a variable CH conversion factor (Y)-based approach that quantitatively relates Y to BW, milk yield (MY), and milk composition. The second objective was to evaluate the predictive performance of the developed models, particularly focusing on differences between the constant and variable Y-based models. A dataset of 266 records, sourced from previous experiments performed using whole-body respiration chambers or headboxes, was used for analysis.

Enhanced Antitumor Immunity by ASP1570, a Novel Diacylglycerol Kinase ζ Inhibitor, Offers a Potential Novel Immunotherapy for Treating Cancer.

Studies of diacylglycerol kinase ζ (DGKζ) in DGKζ knockout mice have revealed its role as an intracellular immune checkpoint in T cells. Although enhancing antitumor immunity by pharmacologic inhibition of DGKζ is desirable, selective DGKζ inhibitors for clinical use remain largely unexplored. In this study, we report a novel, small-molecule DGKζ inhibitor, ASP1570, which is currently under phase 1 development (NCT05083481), and characterize its effect on potential resistance mechanisms against approved immune checkpoint inhibitors in multiple immunosuppressive conditions: not only TGF-β, prostaglandin E2, adenosine, and PD-1 but also cytotoxic T-lymphocyte antigen-4 and T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif.

Biomechanical Comparison of Inside-Out and All-Inside Meniscal Repair in Controlling the Peripheral Gap and Extrusion of the Lateral Meniscus With a Complete Radial Tear: A Cadaveric Study Using a Robotic Simulator.

Background: Although both the classical inside-out and all-inside techniques are performed for the repair of complete radial tears, which should be the standard technique is, to the authors' knowledge, controversial considering the clinical outcomes and biomechanical studies. There are no biomechanical studies of repairs of the lateral meniscus (LM) evaluating the peripheral side gap (peripheral gap) of the radial tear site and extrusion of the LM, which seems to be important in the treatment of radial tears.

Purpose: To compare the inside-out and all-inside meniscal repair techniques by evaluating the peripheral gap and extrusion of the LM with complete radial tear using a 6 degrees of freedom robotic system and fresh-frozen cadavers.

Experience in setting up non-robotic minimally invasive direct coronary artery bypass grafting in a non-routine off-pump coronary artery bypass center.

Background: The safety of minimally invasive direct coronary artery bypass (MIDCAB) has been proven. Nevertheless, reports on clinical outcomes in MIDCAB and the learning curve of this challenging technique in a non-routine off-pump coronary artery bypass (OPCAB) center are still limited. Here, we introduce our clinical outcomes of non-robotic MIDCAB.

Risk of Death in Older Japanese Adults with COVID-19 Caused by the Omicron Variant: a Population-Based Study.

We assessed case fatality rates (CFRs) in adults aged ≥70 years in 10 prefectures in Japan (14.8 million residents) diagnosed between January 2022 and March 2023, when the Omicron variant was dominant in Japan. We selected incident reports on 283,052 cases from participating public health centers reported according to the Infectious Diseases Control Law.

Re-evaluation of the canonical PAF pathway in cutaneous anaphylaxis.

Platelet-activating factor (PAF) is a potent classical lipid mediator that plays a critical role in various diseases such as allergy and nervous system disorders. In the realm of allergy, previous studies suggested that PAF is generated in response to extracellular stimuli and contributes to allergic reactions via PAF receptor (PAFR). However, the sources of endogenous PAF and its pathophysiological dynamics remain largely elusive in vivo.

RetinaViT: Efficient Visual Backbone for Online Video Streams.

In online video understanding, which has a wide range of real-world applications, inference speed is crucial. Many approaches involve frame-level visual feature extraction, which often represents the biggest bottleneck. We propose RetinaViT, an efficient method for extracting frame-level visual features in an online video stream, aiming to fundamentally enhance the efficiency of online video understanding tasks.

In vitro and in vivo evaluation of biohybrid tissue-engineered vascular grafts with transformative H/F MRI traceable scaffolds.

Biohybrid tissue-engineered vascular grafts (TEVGs) promise long-term durability due to their ability to adapt to hosts' needs. However, the latter calls for sensitive non-invasive imaging approaches to longitudinally monitor their functionality, integrity, and positioning. Here, we present an imaging approach comprising the labeling of non-degradable and degradable TEVGs' components for their in vitro and in vivo monitoring by hybrid H/F MRI.

Effect of anti-claudin 18.2 monoclonal antibody zolbetuximab alone or combined with chemotherapy or programmed cell death-1 blockade in syngeneic and xenograft gastric cancer models.

The development of targeted cancer therapies based on monoclonal antibodies against tumor-associated antigens has progressed markedly over recent decades. This approach is dependent on the identification of tumor-specific, normal tissue-sparing antigenic targets. The transmembrane protein claudin-18 splice variant 2 (CLDN18.

Pediatric Synovial Osteochondromatosis of the Knee with Leg Length Discrepancy: A Case Report.

Introduction: Synovial chondromatosis (SC) is very rare among children. We are aware of no reports of patients with SC accompanied by leg length discrepancy (LLD).

Case Report: We describe a case of synovial osteochondromatosis of a 7-year-old boy complicated by LLD.

Relationship between increased knee joint line obliquity after medial open-wedge high tibial osteotomy and patient-reported outcome measures.

Introduction: This study evaluated the correlation between postoperative knee joint line obliquity after medial open-wedge high tibial osteotomy and patient-reported outcome measures excluding excessively overcorrected knees. This study further identified preoperative radiological factors related to the increased postoperative knee joint line obliquity.

Materials And Methods: We retrospectively evaluated patients who underwent medial open-wedge high tibial osteotomy between March 2013 and March 2021.

Factors affecting the post-operative over-constraint after anatomic double-bundle anterior cruciate ligament reconstruction.

Objective: Initial tension at graft fixation is one of key factors for good outcomes in anterior cruciate ligament (ACL) reconstruction. Identifying the pre-operative factors that influence postoperative knee laxity under the anterior tibial load is useful in determining the initial tension at graft fixation. Thus, the purpose of this study was to clarify the pre-operative factors affecting the side-to-side difference in anterior laxity immediately after the anatomic double-bundle ACL reconstruction with a constant initial tension.

Variation among individual beef cattle in methane-to-carbon dioxide ratio measured under on-farm conditions using the sniffer method.

This study proposed a method for measuring the methane (CH )/carbon dioxide (CO ) ratio from individual beef cattle under on-farm conditions and estimated the variance components of the CH /CO ratio. Gas measurements were conducted using 166 Japanese Black cattle group-housed in pens equipped with individual feed bins. The gas containing the animal's breath was measured individually after concentrate feeding by covering the feed bin with a sheet with sampling inlets.

Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy.

The tumor microenvironment (TME) is thought to influence the antitumor efficacy of immuno-oncology agents through various products of both tumor and stromal cells. One immune-suppressive factor is prostaglandin E (PGE), a lipid mediator whose biosynthesis is regulated by ubiquitously expressed cyclooxygenase- (COX-) 1 and inducible COX-2. By activating its receptors, PGE induces immune suppression to modulate differentiation of myeloid cells into myeloid-derived suppressor cells (MDSCs) rather than dendritic cells (DCs).

Satisfactory outcomes after one-stage revision anterior cruciate ligament reconstruction using rectangular tunnel technique.

Purpose: One-stage revision anterior cruciate ligament reconstruction (ACLR) with the anatomic rectangular tunnel (RT) technique using bone-patellar tendon-bone (BTB) grafts results in anatomically precise tunnel placement and secure graft fixation. This study evaluated knee joint laxity and clinical outcomes in terms of femoral tunnel overlap. It was hypothesised that there would be no significant differences in knee joint laxity or clinical outcomes regardless of femoral tunnel overlap.

Effects of fermentative quality of corn silage on lactation, blood metabolites, and rumen fermentation in dairy cows.

We investigated the effect of fermentation quality of corn silage on dry matter intake (DMI), milk yield, ruminal fermentation, methane (CH ) emissions, and plasma metabolites in lactating cows. Six lactating Holstein cows were used in a 2 × 2 crossover design with two dietary treatments containing high quality corn silage with lower pH (high group) or low quality corn silage with higher pH (low group). The cows were fed partial mixed ration (PMR containing 50%DM of each corn silage) ad libitum plus 0.

Ultrasonic Technique for Femoral Tunnel Creation in Anterior Cruciate Ligament Reconstruction.

Bone tunnel creation in the anatomical location is essential in anterior cruciate ligament (ACL) reconstruction with an autogenous graft and is commonly performed with a drill bit matched to graft diameter. Anatomic rectangular tunnel ACL reconstruction with a bone-patellar tendon-bone autograft has been developed to anatomically create bone tunnels inside the ACL footprints and has been reported to achieve excellent outcomes. To make the rectangular tunnel, the surgeon needs to dilate 2 adjacent bone tunnels after creation of 2 round tunnels with a drill bit, while the tunnel wall occasionally cracks during dilating.

Exploring indicators of genetic selection using the sniffer method to reduce methane emissions from Holstein cows.

Objective: This study aimed to evaluate whether the methane (CH4) to carbon dioxide (CO2) ratio (CH4/CO2) and methane-related traits obtained by the sniffer method can be used as indicators for genetic selection of Holstein cows with lower CH4 emissions.

Methods: The sniffer method was used to simultaneously measure the concentrations of CH4 and CO2 during milking in each milking box of the automatic milking system to obtain CH4/CO2. Methane-related traits, which included CH4 emissions, CH4 per energy-corrected milk, methane conversion factor (MCF), and residual CH4, were calculated.