Publications by authors named "Tiao-Chun Cheng"
Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice.
World J Gastroenterol
December 2022
Background: Although expression of interleukin (IL)-34 is upregulated in active ulcerative colitis (UC), the molecular function and underlying mechanism are largely unclear.
Aim: To investigate the function of IL-34 in acute colitis, in a wound healing model and in colitis-associated cancer in IL-34-deficient mice.
Methods: Colitis was induced by administration of dextran sodium sulfate (DSS), and carcinogenesis was induced by azoxymethane (AOM).
Inhibition of Phosphoinositide 3-Kinase Gamma Protects Endothelial Cells via the Akt Signaling Pathway in Sepsis-Induced Acute Kidney Injury.
Kidney Blood Press Res
November 2022
Article Synopsis
- Sepsis is a major cause of death in critically ill patients and is linked to acute kidney injury (AKI), but the underlying mechanisms are not fully understood.
- This study examined the impact of endothelial dysfunction in sepsis-related AKI and evaluated the effects of a specific PI3Kγ inhibitor on kidney damage and endothelial injury in a mouse model.
- Findings revealed that endothelial damage was significantly worse in sepsis-induced AKI, and inhibiting PI3Kγ helped protect and repair kidney endothelium through the Akt signaling pathway, suggesting new treatment targets.
Background: Liver failure (LF) is a life-threatening clinical syndrome characterized by intense systemic inflammation and organ failure(s), leading to a high mortality rate. The pathogenesis of LF is multifactorial, immune response, and gut bacterial translocation are thought to be major contributing factors. Mucosal-associated invariant T (MAIT) cells play a critical role in immune response and gut bacterial translocation.
View Article and Find Full Text PDFCyr61 Alleviates Cholangitis by Inhibiting Cytotoxic Effects of CD8 T Cells on Biliary Epithelial Cells.
Curr Med Sci
December 2021
Objective: Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease. In recent years, researchers have found that cysteine-rich angiogenic inducer 61 (Cyr61, also known as CCN1) has a potential role in reducing portal inflammation in patients with PBC. This study aimed to explore the relationship between Cyr61 and PBC to provide new ideas and an experimental basis for the clinical treatment of PBC.
View Article and Find Full Text PDFMucosal-associated invariant T cells in hepatitis B virus-related liver failure.
World J Gastroenterol
August 2020
Background: Liver failure has high mortality and poor prognosis, and establishing new reliable markers for predicting its prognosis is necessary. Mucosal-associated invariant T (MAIT) cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease, and their potential role in liver failure remains unclear.
Aim: To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus (HBV)-related liver failure.