Chronic PM exposure disrupts intestinal barrier integrity via microbial dysbiosis-triggered TLR2/5-MyD88-NLRP3 inflammasome activation.

Background: PM, a known public health risk, is increasingly linked to intestinal disorders, however, the mechanisms of its impact are not fully understood.

Purpose: This study aimed to explore the impact of chronic PM exposure on intestinal barrier integrity and to uncover the underlying molecular mechanisms.

Methods: C57BL/6 J mice were exposed to either concentrated ambient PM (CPM) or filtered air (FA) for six months to simulate urban pollution conditions.

Phenothiazine versus Phenoxazine: Structural Effects on the Photophysical Properties of NIR-II AIE Fluorophores.

Aggregation-induced emission (AIE) fluorophores with second near-infrared window (NIR-II) fluorescence are very promising for in vivo imaging because they emit fluorescence in an aggregated state and provide desirable imaging resolution and depth. Up to now, only a limited number of NIR-II AIE fluorophores have been developed. Therefore, synthesizing novel NIR-II AIE fluorophores and investigating structural effects on their photophysical properties are very important for the development of AIE probes.

Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus.

The RNA degradosome of the pathogen Staphylococcus aureus regulates the metabolism of RNA, the expression of virulence factors, and the formation of biofilms. It is composed of the RNases J1/J2, RNase Y, CshA, PNPase, Enolase, Pfk, and a newly identified component, RnpA. However, the function and new partners of RnpA in RNA degradosome remain unknown.