IL-23 Receptor Agonism by Mulberroside C Activates the RASGRP1/RAS/ERK Pathway Contributing to Leukopenia Treatments.

Chemotherapy- and radiotherapy-induced leukopenia is a common challenge in cancer treatment, with a significant dearth of effective therapeutic options. IL-23 receptor (IL-23R) signaling holds the potential for promoting neutrophil generation and maturation, yet the underlying mechanisms remain elusive. This study investigates the molecular mechanism and efficacy of Mulberroside C (MC) in alleviating leukopenia via IL-23R signaling.

Synthesis, cytotoxicity and HQSAR study of amides-fused isosteviol derivatives as potential anti-colorectal cancer agents.

A series of novel amide-fused isosteviol derivatives were designed and synthesized. Their cytotoxicities in vitro against HCT-116 cells were screened. The preliminary bioassays indicated that most of the title compounds exhibited noteworthy cytotoxicity.

[Effects of five Chinese herbs on human demodicid mites ].

Objective: To research the effects of five Chinese herbs of , pine needles and on human demodicid mites .

Methods: The human demodicid mites were acquired with the cellophane tape method. The ethanol heat reflux extractions were carried out on the 5 kinds of Chinese herbs to be studied and as the positive control, so as to get the herbal extracts.

Molecular mechanisms of Bombyx batryticatus ethanol extract inducing gastric cancer SGC-7901 cells apoptosis.

Bombyx batryticatus is a traditional Chinese medicine. To understand apoptotic effect of B. batryticatus ethanol extract (BBE), we investigated the role of BBE in inducing apoptosis of human gastric cancer cells SGC-7901.