Emergency peritoneal dialysis via haemodialysis catheter for paediatric acute kidney injury in low-income settings: a life-saving procedure.

Background: The percutaneous insertion of a peritoneal dialysis (PD) catheter by a nephrologist offers a plausible alternative to surgical insertion, improving access to dialysis. We report the experience of the paediatric nephrology unit in Dakar, Senegal, initiating PD for children with acute kidney injury (AKI), using a haemodialysis catheter inserted via a modified Seldinger technique. This approach was chosen due to its availability and cost-free provision, addressing resource constraints effectively.

The Double-Icodextrin Dose Randomized Controlled Trial of a Double Icodextrin Dose for Older Patients on Incremental Continuous Ambulatory Peritoneal Dialysis.

Introduction: Icodextrin enhances ultrafiltration (UF) in patients on peritoneal dialysis (PD) but is restricted to 1 bag/d, according to regulatory authorities. The Double-Icodextrin Dose (DIDo) study is a prospective randomized trial investigating the superiority and safety of using 2 bags/d versus 1 bag/d of icodextrin to extend incremental (3 bags/d) continuous ambulatory PD (CAPD) duration in older incident patients.

Methods: After a 2-month "run-in" period, the patients were randomized to 2 icodextrin ("double dose") + 1 glucose or 1 icodextrin ("single dose") + 2 glucose dialysates daily.

The diversity of peritoneal dialysis care trajectories: A study based on the REIN registry and SNDS database.

Introduction: The integrated care model considers sequences of kidney replacement therapies rather than individual modalities. Data from conventional registries describing trajectories are partial. The aim was to provide a complete description of the peritoneal dialysis pathway.

Outcomes on peritoneal dialysis in patients with primary kidney disease related to multiple myeloma: A cohort study with data from the French Language Peritoneal Dialysis Registry.

BackgroundKidney impairment (KI) is a frequent complication of multiple myeloma (MM), with chronic kidney disease (CKD) often necessitating dialysis. Peritoneal dialysis (PD) offers quality-of-life advantages over haemodialysis (HD), yet its use in patients with CKD secondary to MM (CKD-MM) remains understudied. This study investigates the characteristics and outcomes of PD in CKD-MM patients compared to those with other kidney diseases.

Renal Cell Carcinoma in Native Kidney After Kidney Transplantation: A Multicenter Case Control Study With a Focus on Screening Strategy.

Renal cell carcinoma (RCC) of native kidney is more prevalent after kidney transplantation than in the general population. Risk factors and the value of screening remain unclear. We conducted a multicenter case-control study in kidney transplant recipients transplanted between 1989 and 2017.

Safety and Efficacy of Oral Direct Factor Xa Inhibitors in Patients With Nephrotic Syndrome: Results From a National Retrospective Study.

Introduction: The optimal management of thromboembolism (TE) in patients with nephrotic syndrome (NS) remains challenging. Until now, anticoagulation therapy for NS consisted of vitamin K antagonists (VKAs) or heparin. Data on direct oral anticoagulant (DOAC) use in NS are limited, and their safety and convenience have been well-demonstrated in other indications.

Moderately elevated ambient temperature is associated with mortality in dialysis patients, but not in transplant patients.

Background: In many parts of the world, heat waves have been associated with excess morbidity and mortality in the general population. Studies on the effects of high-temperature exposure in kidney transplantation are lacking and are scare in dialysis patients. The aim of this study was to investigate the association between high temperatures and mortality for chronic kidney disease (CKD) stage 5 patients treated with dialysis or with a kidney graft in France using various definition of elevated temperature.

Stroke risk in ADPKD patients treated by dialysis: a retrospective study.

Background And Hypothesis: The risk of ischaemic or haemorrhagic strokes in patients living with end-stage renal disease and receiving replacement therapy is more than double that of non-dialysed individuals. Autosomal dominant polycystic kidney disease (ADPKD) is an inherited systemic disorder associated with renal and non-renal manifestations, including intracerebral aneurysms. The role of underlying nephropathy in determining the onset of the stroke is unclear.

Efficacy of slow daily home hemodialysis with internal convection on removal of uremic toxins using the Physidia S3 monitor.

Home hemodialysis, despite its recognized clinical benefits such as improved cardiac health and enhanced quality of life, remains underutilized worldwide. This study aims to evaluate the efficacy of home hemodialysis within slow daily dialysis programs, employing the Physidia S3 monitor. A prospective trial was conducted with 16 stable patients suffering from end-stage kidney disease and undergoing home hemodialysis.

Bimodal solutions in peritoneal dialysis: what can we expect from different glucose volumes added to the icodextrin bag? Data from a simulation procedure.

Background: Ultrafiltration (UF) insufficiency in peritoneal dialysis (PD) often leads to transfer to hemodialysis. Therefore, strategies to prolong time on therapy are needed. The use of a combined crystalloid and colloid solution, also called bimodal PD, can help improve UF.

[Peritoneal dialysis in the management of acute kidney injury in children and young adults within French-speaking countries - Partnership between the Société francophone de néphrologie, dialyse et transplantation (SFNDT) and the Saving Young Lives program].

Acute kidney injury (AKI) is a common event associated with a high mortality rate in the absence of adequate treatment. In lower-income countries, peritoneal dialysis (PD) plays an essential role in the treatment of AKI, especially in the paediatric population. In 2013, the International Society of Nephrology (ISN) launched the ‘0 by 25’ project, which aims to eliminate preventable deaths from AKI worldwide by 2025.

Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database.

Objectives: The objective is to investigate the association between antidepressant drugs intake and falls reporting, as well as the potential mediators in-between, in older adults.

Methods: In VigiBase®, the World Health Organization's pharmacovigilance database, we performed a disproportionality analysis to probe the putative associations between each antidepressant drugs class (non-selective monoamine reuptake inhibitors [NSMRIs], selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs], alpha-2-adrenergic receptor antagonists, and "other antidepressants") and reports of falls in people aged 65 and over (NCT05628467). The reporting odds ratios and their 95% confidence interval were derived from logistic regression models with adjustment for confounders.

Patient on Peritoneal Dialysis Transfers to Hemodialysis: Causes and Associated Risks.

Key Points: Nurse assistance is associated with a lower risk of transfer to hemodialysis for dialysis inadequacy after 6 months and for infection in the first 18 months. Compared with automated peritoneal dialysis (PD), continuous ambulatory PD is associated with a higher risk of transfer to hemodialysis for mechanical issue during the first 18 months. Suboptimal starters have a higher risk of transfer to hemodialysis due to psychosocial challenges in the first 6 months of PD.

Early-Onset Peritonitis and Outcomes of Peritoneal Dialysis: A Cohort Study with Data from the RDPLF.

Introduction: Peritonitis occurring within the first months on peritoneal dialysis (PD) has been associated with poorer PD outcomes. Whether early peritonitis is a risk factor for transfer to haemodialysis in the long term is a matter of investigation.

Methods: This retrospective study was conducted using data from the French Language PD Registry of incident PD patients between 2002 and 2018.

A convergent mixed methods to study registration on kidney transplantation waiting list refusal by women and men on dialysis in France.

Not all patients on dialysis want to be registered on the kidney transplantation (KT) waiting list and undergo transplantation. The aim of this convergent mixed methods study was to determine the features of patients refusing to be registered on the KT waiting list and the reasons. Quantitative data on all 2017-2019 incident 18-85-year-old dialysis patients, eligible for KT, were extracted from the REIN registry in France.

The Time-Dependent Effect of Assistance on Peritoneal Dialysis Duration: An Analysis of Data from the French Language Peritoneal Dialysis Registry.

Key Points: It is unknown whether the benefit of assisted peritoneal dialysis (PD) programs appears immediately after PD initiation or rather after some time spent on PD. The protective effect of assisted PD on the risk of transfer to hemodialysis was not constant over time; it started after the first 6 months on PD. Assisted PD programs should be sustainable for at least 6 months to observe their benefits.

Safety and efficacy of apixaban versus warfarin in peritoneal dialysis patients with non-valvular atrial fibrillation: protocol for a prospective, randomised, open-label, blinded endpoint trial (APIDP2).

Introduction: Several randomised controlled trials have demonstrated that novel oral anticoagulants are safer compared with vitamin K antagonists for the management of non-valvular atrial fibrillation (NVAF) to prevent thromboembolic events in the general population. There is a growing interest in the use of apixaban in patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD) but there is a lack of randomised data in this population.

Methods And Analysis: APIDP2 is a prospective parallel, randomised, open-label, blinded endpoint trial involving patients with ESRD undergoing chronic PD who have NVAF.

[Nurse-assisted arterio-venous fistula cannulation during home hemodialysis: first results of the DIADIDEAL study].

Introduction: We have launched a pilot study, called DIADIDEAL, to propose nurse-assistance at home for arterio-venous fistula (AVF) cannulation in home hemodialysis (HHD) patients. The aim of the present study was to describe enrollment of the patients and their nurses.

Materials: All prevalent HD patients on 30th November 2018 with no medical contraindication to HDD treatment and all incident patients on dialysis from the 30th November 2018 to the 21st April 2023 were eligible.

[Why is health literacy an essential component of health of individuals with chronic kidney disease].

Health literacy (HL) is the ability of individuals to access, understand and use health information to improve their health. It is a multidimensional and contextual concept, whose definition has been enriched over time. Considered both as a health risk factor and a skill to be developed by individuals, HL also depends on the healthcare system in which patients have to navigate, and on healthcare professionals’ awareness of this concept.