When the cell needs to respond to the environment: A chromatin-splicing love affair.

Alternative splicing enables cells to acquire novel phenotypic traits for adaptation to changes in the environment. However, the mechanisms that allow these dynamic changes to occur in a timely and sustained manner remain unknown. Recent investigations unveiled a new regulatory layer important for splicing dynamics and memory: the chromatin.

Post-transcriptional gene regulation: From mechanisms to RNA chemistry and therapeutics.

A better understanding of the RNA biology and chemistry is necessary to then develop new RNA therapeutic strategies. This review is the synthesis of a series of conferences that took place during the 6th international course on post-transcriptional gene regulation at Institut Curie. This year, the course made a special focus on RNA chemistry.