Towards Data-Driven Science Literacy: Extracting Psycholinguistic Markers in Vaping-Related Online Peer Interactions.

Social media debates on e-cigarettes raise public health concerns due to evolving evidence and conflicting guidelines. We analyzed 25,127 vaping-related comments to explore how users discuss vaping-related topics. Our analysis revealed 25 topics grouped into three parent topics: positive effects of vaping, negative effects of vaping, and vaping-related news & information.

Enhancing Digital Health Development Through Speech Act Theory: Application to Peripartum Depression Management.

The peripartum period is a time of complex transition into motherhood when women may develop peripartum depression (PPD). Digital information sources can help prevent and monitor symptoms through social support and mental health knowledge. However, few studies have characterized the content and form of peer interactions in PPD online forums to inform interventions.

Ocular injuries and outcomes secondary to Nerf guns in an optometric setting.

Clinical Relevance: Nerf guns can lead to significant ocular injury. Understanding the incidence and types of complications that can result can lead to improved diagnoses, management, and prevention.

Background: The intention of this study is to characterise the incidence, ocular findings, and specific visual outcomes associated with Nerf gun injuries at the Illinois College of Optometry, an academic optometric setting.

Toward Personalized Digital Experiences to Promote Diabetes Self-Management: Mixed Methods Social Computing Approach.

Background: Type 2 diabetes affects nearly 34.2 million adults and is the seventh leading cause of death in the United States. Digital health communities have emerged as avenues to provide social support to individuals engaging in diabetes self-management (DSM).

Pediatric High Blood Pressure Recognition Associated With Electronic Decision Support: A Cohort Analysis.

Background: Pediatric high blood pressure (BP) predicts future cardiovascular disease events. High BP is improperly measured, underrecognized, and undermanaged especially in disadvantaged populations. In a large, diverse, academic pediatric practice, we detail the associations of a comprehensive initiative with high BP provider recognition.

Digital health technologies for high-risk pregnancy management: three case studies using Digilego framework.

Objective: High-risk pregnancy (HRP) conditions such as gestational diabetes mellitus (GDM), hypertension (HTN), and peripartum depression (PPD) affect maternal and neonatal health. Patient engagement is critical for effective HRP management (HRPM). While digital technologies and analytics hold promise, emerging research indicates limited and suboptimal support offered by the highly prevalent pregnancy digital solutions within the commercial marketplace.

Sequencing conversational turns in peer interactions: An integrated approach for evidence-based conversational agent for just-in-time nicotine cravings intervention.

Background: Risky health behaviors place an enormous toll on public health systems. While relapse prevention support is integrated with most behavior modification programs, the results are suboptimal. Recent advances in artificial intelligence (AI) applications provide us with unique opportunities to develop just-in-time adaptive behavior change solutions.

Digital health technologies for peripartum depression management among low-socioeconomic populations: perspectives from patients, providers, and social media channels.

Background: Peripartum Depression (PPD) affects approximately 10-15% of perinatal women in the U.S., with those of low socioeconomic status (low-SES) more likely to develop symptoms.

Lessons Learned From Interdisciplinary Efforts to Combat COVID-19 Misinformation: Development of Agile Integrative Methods From Behavioral Science, Data Science, and Implementation Science.

Background: Despite increasing awareness about and advances in addressing social media misinformation, the free flow of false COVID-19 information has continued, affecting individuals' preventive behaviors, including masking, testing, and vaccine uptake.

Objective: In this paper, we describe our multidisciplinary efforts with a specific focus on methods to (1) gather community needs, (2) develop interventions, and (3) conduct large-scale agile and rapid community assessments to examine and combat COVID-19 misinformation.

Methods: We used the Intervention Mapping framework to perform community needs assessment and develop theory-informed interventions.

Discerning conversational context in online health communities for personalized digital behavior change solutions using Pragmatics to Reveal Intent in Social Media (PRISM) framework.

Background: Online health communities (OHCs) have emerged as prominent platforms for behavior modification, and the digitization of online peer interactions has afforded researchers with unique opportunities to model multilevel mechanisms that drive behavior change. Existing studies, however, have been limited by a lack of methods that allow the capture of conversational context and socio-behavioral dynamics at scale, as manifested in these digital platforms.

Objective: We develop, evaluate, and apply a novel methodological framework, Pragmatics to Reveal Intent in Social Media (PRISM), to facilitate granular characterization of peer interactions by combining multidimensional facets of human communication.

Binge alcohol consumption exacerbates high-fat diet-induced neurobehavioral anomalies: Possible underlying mechanisms.

The current study aimed to validate the mice model of alcohol (ALC), high-fat diet (HFD), and HFD + ALC combination affecting neurobehavioral and neurochemical anomalies via inflammatory cascade, lowered neurogenesis, enhanced microgliosis, reactive astrogliosis, activated IDO-1 (indoleamine 2,3-dioxygenase), and reduce CHAT (choline acetyltransferase) signaling in the hippocampus (HIP). The adult male Swiss albino mice were provided with ALC (3-15%) and in-house prepared HFD for continuous 12 weeks. The HFD and HFD + ALC consumption impacted the liver and mediated HIP damage.

Latent Linguistic Motifs in Social Media Postings Resisting COVID-19 Misinformation.

Social media has become a predominant source of information for many health care consumers. However, false and misleading information is a pervasive problem in this context. Specifically, health-related misinformation has become a significant public health challenge, impeding the effectiveness of public health awareness campaigns and resulting in suboptimal responsiveness to the communication of legitimate risk-related information.

Towards Digestible Digital Health Solutions: Application of a Health Literacy Inclusive Development Framework for Peripartum Depression Management.

Women of low income and education have lower levels of peripartum depression (PPD) literacy, limiting their ability to recognize symptoms and make informed healthcare decisions. Existing digital solutions and underlying development frameworks for PPD lack an integrative approach addressing health literacy and related disparities. Therefore, we develop an integrative framework for digital content engineering in PPD self-management consisting of (a) user needs analysis, (b) inclusion of eHealth literacy principles (science and health literacy), and (c) mapping user needs to the Behavioral Intervention Technology model.

Pragmatics to Reveal Intent in Social Media Peer Interactions: Mixed Methods Study.

Background: Online health communities (OHCs) have emerged as the leading venues for behavior change and health-related information seeking. The soul and success of these digital platforms lie in their ability to foster social togetherness and a sense of community by providing personalized support. However, we have a minimal understanding of how conversational posts in these settings lead to collaborative societies and ultimately result in positive health changes through social influence.

Analysis of Online Peripartum Depression Communities: Application of Multilabel Text Classification Techniques to Inform Digitally-Mediated Prevention and Management.

Peripartum depression (PPD) is a significant public health problem, yet many women who experience PPD do not receive adequate treatment. In many cases, this is due to social stigmas surrounding PPD that prevent women from disclosing their symptoms to their providers. Examples of these are fear of being labeled a "bad mother," or having misinformed expectations regarding motherhood.

Transitions Between Electronic and Combustible Cigarettes: A Mixed Methods Analysis of Peer Interactions in an Online Community for Tobacco Cessation.

The growing popularity of e-cigarettes is a public health concern. There is an emerging need to understand the pathways between electronic and combustible modes due to the specialized nature of risks associated with each transition. Online social media has become the most dominant knowledge space for these evolving behaviors, and as such, can provide unique opportunities for modeling switching patterns.

Revealing Intention In Health-related Peer Interactions: Implications For Optimizing Patient Engagement In Self-health Management.

Risky health behaviors such as poor diet, physical inactivity are the main contributors to the development of diabetes, one of the major causes of death and disability in the United States. Online health communities provide new avenues for individuals to efficiently manage their health conditions and adopt a positive lifestyle. So far, analysis of health-related online social exchanges has focused solely on communication content and structure of social ties, ignoring implicit user intentions underlying communication exchanges.

Social Media as a Research Tool (SMaaRT) for Risky Behavior Analytics: Methodological Review.

Background: Modifiable risky health behaviors, such as tobacco use, excessive alcohol use, being overweight, lack of physical activity, and unhealthy eating habits, are some of the major factors for developing chronic health conditions. Social media platforms have become indispensable means of communication in the digital era. They provide an opportunity for individuals to express themselves, as well as share their health-related concerns with peers and health care providers, with respect to risky behaviors.

Diabetes Self-Management in the Age of Social Media: Large-Scale Analysis of Peer Interactions Using Semiautomated Methods.

Background: Online communities have been gaining popularity as support venues for chronic disease management. User engagement, information exposure, and social influence mechanisms can play a significant role in the utility of these platforms.

Objective: In this paper, we characterize peer interactions in an online community for chronic disease management.

Characterization of Behavioral Transitions Through Social Media Analysis: A Mixed-Methods Approach.

Unhealthy behaviors are a socioeconomic burden and lead to the development of chronic diseases. Relapse is a common issue that most individuals deal with as they adopt and sustain a positive healthy lifestyle. Proper identification of behavioral transitions can help design agile, adaptive, and just-in-time interventions.

Cognitive deficits induced by combined exposure of stress and alcohol mediated through oxidative stress-PARP pathway in the hippocampus.

Several studies reported that stress can enhance the consumption of alcohol in humans and animals. However, the combinatorial effect of stress and alcohol on cognitive function and neurochemical alterations is quite understudied. In the present study, we have elucidated the involvement of oxidative stress-PARP cascade in alcohol and restraint stress (RS)-exposed animals using a PARP inhibitor, 1,5-isoquinolinediol (3mg/kg for 14days).

Edaravone alleviates cisplatin-induced neurobehavioral deficits via modulation of oxidative stress and inflammatory mediators in the rat hippocampus.

Cisplatin is a chemotherapeutic agent used in the treatment of malignant tumors. A major clinical limitation of cisplatin is its potential toxic effects, including neurotoxicity. Edaravone, a potent free radical scavenger, has been reported to have the neuroprotective effect against neurological deficits.

Piperine Augments the Protective Effect of Curcumin Against Lipopolysaccharide-Induced Neurobehavioral and Neurochemical Deficits in Mice.

The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus. Mice were treated with curcumin (100, 200, and 400 mg/kg, p.o.

Fused primary first mandibular macromolar with a unique relation to its permanent successors: A rare tooth anomaly.

Dental anomalies of number and forms may occur in the primary and permanent dentition. Various terms have been used to describe dental twinning anomalies: Germination, fusion, concrescence, double teeth, conjoined teeth, twinned teeth, geminifusion, and vicinifusion. Fused tooth is a developmental anomaly that is seen more frequently in the primary than the permanent dentition.