Publications by authors named "Takuya Fukuoka"

We report the case of a 91-year-old man with varicella zoster virus (VZV) meningoencephalitis who presented with acute progressive delirium. Brain MRI revealed multiple small vessel lesions, and cerebrospinal fluid testing came back positive for VZV DNA by polymerase chain reaction. We assume that VZV had reactivated since he was elderly and had lung cancer.

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Article Synopsis
  • The study focuses on the contamination of green turtles in the Ogasawara Islands, Japan, by benzotriazole-type ultraviolet stabilizers (BUVSs) and polychlorinated biphenyls (PCBs).
  • BUVSs were found in the adipose tissue of 19 out of 21 turtles, with specific compounds like UV-327, UV-326, and UV-328 being frequently detected at varying concentrations.
  • The research suggests that the presence of BUVSs in turtles may be more related to plastic debris in the environment rather than just their diet, as high BUVS levels don't always correspond with high PCB levels.
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Diving bradycardia is a reduction in the heart rate mediated by the parasympathetic system during diving. Although diving bradycardia is pronounced in aquatic mammals and birds, the existence of this response in aquatic reptiles, including sea turtles, remains under debate. Using the parasympathetic blocker atropine, we evaluated the involvement of the parasympathetic nervous system in heart rate reduction of loggerhead sea turtles (Caretta caretta) during voluntary diving in tanks.

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On 10 August 2021, a face mask (14 cm × 9 cm) was found in the feces of a juvenile green turtle, by-caught alive in a set net off the northeast coast of Japan. Although sea turtles have been monitored in this region over the last 15 years (n = 76), face masks had never been found before the Covid-19 pandemic and this is the first detection. Fourier-transform infrared spectroscopy identified the mask as polypropylene.

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To measure the heart rate of unrestrained sea turtles, it has been believed that a probe must be inserted inside the body owing to the presence of the shell. However, inserting the probe is invasive and difficult to apply to animals in the field. Here, we have developed a non-invasive heart rate measurement method for some species of sea turtles.

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Animals with high resting metabolic rates and low drag coefficients typically have fast optimal swim speeds in order to minimise energy costs per unit travel distance. The cruising swim speeds of sea turtles (0.5-0.

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The metabolic rate and activity of sea turtles generally decreases with decreasing seasonal ambient temperature. Juvenile loggerhead turtles in the Mediterranean Sea made prolonged inactive dives (>400 min), indicating a state of dormancy during the cold winter period. However, seasonal differences in dive duration were not detected in juvenile loggerheads in the western North Pacific, even though the ambient water temperature changed by more than 10°C.

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We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter single-photon emission computed tomography (DAT SPECT) using I-ioflupane and found marked presynaptic dopamine dysfunction in the bilateral striatum. This is the first reported case in which the initial symptom of fatal familial insomnia was parkinsonism and in which the dopamine transporter function was evaluated by DAT SPECT.

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Objective The purpose of this study was to clarify the clinical features of ischemic patients for whom cigarette smoking was the sole risk factor for ischemic stroke. Methods Among the 1,329 patients (male, n=833; female, n=496) with acute ischemic stroke who were admitted to our hospital between April 2005 and September 2016, 346 (26%) were smokers [male, n=308 (36.9%); female, 38 (7.

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In the present report, we discuss the case of a 66-year-old woman with isolated unilateral hypoglossal paralysis due to cerebral infarction in the centrum semiovale. To date, it has hardly been discussed where the corticolingual tract passes through in the centrum semiovale. Brain magnetic resonance imaging revealed a small ischemic infarction in the contralateral centrum semiovale.

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A 70-year-old man developed urinary retention in the early stages of herpes simplex virus (HSV) type-1 encephalitis. A nerve conduction study suggested latent myeloradiculitis. This is the first report of human herpes simplex virus-1 encephalitis followed by urinary retention at early stage from the onset like the Elsberg syndrome.

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Objective Decompressive craniectomy (DC) in patients with malignant middle cerebral artery (MCA) infarction is known to decrease the mortality rate. However, the functional outcomes (communication and oral intake) of this procedure remain unclear. Most patients with malignant MCA infarction exhibit a loss of consciousness, which may be principally governed by the thalamus.

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Ingestion of artificial debris is considered as a significant stress for wildlife including sea turtles. To investigate how turtles react to artificial debris under natural conditions, we deployed animal-borne video cameras on loggerhead and green turtles in addition to feces and gut contents analyses from 2007 to 2015. Frequency of occurrences of artificial debris in feces and gut contents collected from loggerhead turtles were 35.

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We herein describe the case of an 18-year-old girl who presented with dizziness and headache in 2012. In 2013, brain magnetic resonance imaging revealed multiple intracerebral small lesions and intracerebral hydrocephalus. She was diagnosed with neurosarcoidosis following a brain biopsy.

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Article Synopsis
  • The study investigates the impact of dabigatran, an oral anticoagulant, on the severity and prognosis of ischemic strokes in patients with non-valvular atrial fibrillation (NVAF).
  • Researchers compared patients on regular dabigatran therapy to those who discontinued it, finding that those on treatment had significantly lower NIHSS scores (indicating less severe stroke) and better outcomes at discharge.
  • The results suggest that dabigatran might play a beneficial role in reducing stroke severity even after an ischemic event occurs.
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The purpose of this study was to investigate the behavior of platelets (rolling and adhesion) in cerebral microvessels of angiotensin II type-2 receptor-knockout (AT2RKO) mice after transient bilateral carotid artery occlusion using intravital fluorescence microscopy. Twenty AT2RKO mice, consisting of 11 mice in the sham group and 9 mice in the ischemia reperfusion group (reperfusion after 15 min of bilateral, total carotid artery occlusion) were used in this study. The hole traversed the bone and dura mater, but arachnoid, pia mater, and cerebral parenchyma were preserved.

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Background: Essential thrombocythemia (ET) is considered a rare cause of stroke partly because it is not detected if the platelet count is not elevated. However, early detection of ET is important because thrombosis can recur frequently, unless adequately treated.

Methods: We retrospectively collected data from 10 stroke cases with ET.

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Article Synopsis
  • Clopidogrel is used to prevent non-cardiogenic ischemic stroke, but individual responses vary, and smoking may affect how patients respond to the drug.
  • A study of 209 stroke patients found that smokers had significantly lower platelet aggregation compared to non-smokers, indicating better responsiveness to clopidogrel.
  • Overall, smokers showed a lower incidence of clopidogrel resistance, suggesting that smoking may enhance the drug's effectiveness in preventing stroke recurrence.
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Background: We compared the clinical outcomes of persistent atrial fibrillation (PeAF) and paroxysmal atrial fibrillation (PAF) in patients with cardioembolic stroke caused by nonvalvular atrial fibrillation (NVAF) because the nature of the fibrillation can cause persistent cerebral infarction.

Methods: We classified 619 of 964 patients hospitalized with cardioembolic stroke between April 2007 and December 2013 within 24 hours of onset as having PeAF (n = 447) and PAF (n = 172) according to a retrospective analysis of their clinical records, including National Institutes of Health Stroke Scale (NIHSS) scores on admission, clinical outcomes (modified Rankin Scale [mRS] scores) at 90 days after admission, and major cerebral artery occlusion.

Results: The PeAF group was significantly older (P < .

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Background: Isolated brain infarction in the anterior cerebral artery (ACA) territory is rare, and its etiology has not yet been fully elucidated. Thus, we aimed to determine the etiologic and clinical characteristics of patients with isolated ACA territory infarction due to arterial dissection.

Methods: Of 2315 patients with acute cerebral infarction admitted to our hospital between April 2007 and September 2013, 34 patients (1.

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A 67-year-old man with a history of prostatic hypertrophy developed behavioral anomalies and a fever. At admission, diffusion-weighted brain magnetic resonance imaging (MRI) indicated a high-intensity signal lesion on both sides of the cerebral hemisphere. Immediately after hospitalization, he developed paralysis of the left side of the body.

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Background: Previous studies show that 6%-31% of transient ischemic attacks (TIA) were caused by cardiogenic cerebral embolism (cardioembolic TIA). As prompt initiation of therapy is essential in TIA to prevent subsequent strokes, determining their cause is important. In this study, we aim to determine the features of cardioembolic TIA and to compare them with those of noncardioembolic etiology.

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Background: We investigated the effect of rosuvastatin, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on serum lipids and arteriosclerosis in dyslipidemic patients with cerebral infarction.

Methods: The subjects were 24 patients with noncardiogenic cerebral infarction complicated by dyslipidemia (low-density lipoprotein cholesterol [LDL-C] ≥ 140 mg/dL). Serum lipids and highly sensitive C-reactive protein (hs-CRP) were measured at the start of the study and at 3 and 12 months after the initiation of oral rosuvastatin (5 mg/day).

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