Publications by authors named "Takashi Agari"

Background: Valve reversal following lumboperitoneal shunt (LPS) surgery can lead to valve mis adjustment or failure, potentially causing complications such as overdrainage and chronic subdural hematoma. While proper fixation and placement depth are considered important for prevention, effective strategies have not been well established.

Methods: We retrospectively analyzed 30 LPS procedures performed at our institution from January 2021 to December 2024.

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Spontaneous acute subdural hematoma (SDH) is a rare but potentially life-threatening condition. We present the case of a 73-year-old man with spontaneous acute SDH in which a computed tomography angiography (CTA) demonstrated contrast extravasation from a cortical artery. The patient was successfully treated with endoscopic hematoma evacuation via a small craniotomy, minimizing surgical invasiveness.

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Abdominal cerebrospinal fluid (CSF) pseudocysts are rare complications of shunt surgery, predominantly reported in pediatric patients undergoing a ventriculoperitoneal (VP) shunt. In contrast, their occurrence following lumboperitoneal (LP) shunt is exceptionally uncommon. We report the case of a 76-year-old woman who presented with recurrent symptoms, including gait disturbance and cognitive decline, approximately three years after undergoing LP shunt placement for idiopathic normal pressure hydrocephalus.

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Background: Patients with previous abdominal surgeries are often considered unsuitable for lumboperitoneal (LP) or ventriculoperitoneal shunt placement due to the potential risk of peritoneal adhesions. This study evaluates the safety and efficacy of the lateral abdominal approach for LP shunt insertion in such patients.

Methods: A retrospective analysis was performed on 21 patients who underwent LP shunt placement for idiopathic normal pressure hydrocephalus (iNPH) via the lateral abdominal approach at our institution between January 2021 and December 2022.

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Article Synopsis
  • - A 59-year-old woman developed complex regional pain syndrome in her right arm after surgery for cubital tunnel syndrome, leading to treatment with spinal cord stimulation (SCS) that initially helped her pain.
  • - Four years later, she experienced motor weakness on her left side and reduced effectiveness of the SCS therapy, which prompted an MRI revealing significant compression of her cervical spinal cord due to epidural granulation tissue.
  • - After surgically removing the granulation tissue, her motor weakness improved, and histological tests indicated that an allergic reaction to materials in the SCS setup caused the tissue fibrosis.
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A 49-year-old woman with a family history of Moyamoya disease presented with sudden onset of right hemiparesis without headache. Magnetic resonance imaging (MRI) of the head revealed a cerebral infarct in the left corona radiata, and magnetic resonance angiography (MRA) revealed severe stenosis of the bilateral internal carotid, middle, anterior, and posterior cerebral arteries. Antithrombotic therapy improved her symptoms.

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In patients presenting neck pain and hemiparesis, differentiation between cerebral infarction and cervical spinal epidural hematoma is vital yet challenging, particularly when magnetic resonance imaging (MRI) is not feasible. A 59-year-old woman presented with a sudden onset of left-sided hemiparesis and neck pain. MRI was contraindicated because the patient underwent embolization in childhood.

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Deep brain stimulation (DBS) has emerged as an important therapeutic option for several movement disorders; however, the management of acute complications, such as acute subdural hematoma (ASDH), remains challenging. This is the case of a 71-year-old woman with Parkinson's disease who developed ASDH 12 years after bilateral DBS placement. On admission with altered consciousness, imaging revealed significant displacement of the DBS electrodes because of the hematoma.

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Background: Pallidal deep brain stimulation (GPi-DBS) is effective for treating myoclonus and dystonia caused by SGCE mutations (DYT-SGCE, DYT11). However, it is unknown whether GPi-DBS is effective for the treatment of myoclonus-dystonia which is not associated with the SGCE gene mutations. In this study, we investigated the efficacy of GPi-DBS in treating myoclonus-dystonia in SGCE mutation-negative cases.

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The availability of long-term (>2 years) safety outcomes of spinal cord stimulation (SCS) remains limited. We evaluated safety in a global SCS registry for chronic pain. Participants were prospectively enrolled globally at 79 implanting centers and followed out to 3 years after device implantation.

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Background: Spinal lipomas sometimes involve various ectopic tissues originating from the ectoderm, mesoderm, and endoderm in the process of morphological development.

Observations: A 29-year-old male patient with myolipoma of the conus medullaris at the S2 and S3 levels was described. The unusual finding, involuntary muscle contraction, was presented in an operative video and a literature review.

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Background: The major surgical treatment for Parkinson's disease (PD) is deep brain stimulation (DBS), but a less invasive treatment is desired. Vagus nerve stimulation (VNS) is a relatively safe treatment without cerebral invasiveness. In this study, we developed a wireless controllable electrical stimulator to examine the efficacy of VNS on PD model rats.

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Article Synopsis
  • A multicenter retrospective study assessed the effectiveness of spinal cord stimulation (SCS) for patients suffering from central poststroke pain (CPSP), contradicting previous beliefs that SCS was ineffective for this condition.
  • The study involved 166 patients, showing significant pain reduction—42% decrease in pain scores and 64% experienced a notable improvement during trial stimulation, with 64% continuing to long-term device implantation.
  • Factors linked to better outcomes included younger age, minimal sensory disturbance, cervical lead implantation, and treatment focused on upper-limb pain.
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Background: In this study we analyze new clinical data in the use of spinal cord stimulation (SCS) for the treatment of pain and motor symptoms in patients with Parkinson's Disease (PD), as both a singular bioelectric therapy and as a salvage therapy after deep brain stimulation (DBS).

Methods: Fifteen patients were recruited and had percutaneous electrodes implanted at the level of the thoracic or cervical spine. Participants were set to one of three stimulation modes: continuous tonic stimulation, continuous Burst stimulation (40 Hz, 500 Hz, 1000 μs), or cycle mode (on time of 10-15 s, off time of 15-30 s) with Burst (40 Hz, 500 Hz, 1000 μs).

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Background: Details of the somatotopy within the subthalamic nucleus (STN) are still poorly understood; however, the STN is a common target of deep brain stimulation (DBS) for Parkinson disease.

Objective: To examine somatotopic organization within the STN and identify optimal stimulation sites from 77 surgical cases with microelectrode recording.

Methods: STN-DBS was performed for 77 patients with Parkinson disease between 2010 and 2014.

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Objective: In Parkinson's disease (PD), abnormal postures are often accompanied, which interfere with rehabilitation and subsequent functional recovery. This study investigated the relationship between clinical characteristics and improvement in abnormal postures of PD patients who received subthalamic nucleus deep brain stimulation (STN-DBS).

Methods: Seventy-four PD patients were included in this study.

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The success of deep brain stimulation (DBS) depends heavily on surgical accuracy, and brain shift is recognized as a significant factor influencing accuracy. We investigated the factors associated with surgical accuracy and showed the effectiveness of a dural sealant system for preventing brain shift in 32 consecutive cases receiving DBS. Thirty-two patients receiving DBS between March 2014 and May 2015 were included in this study.

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We investigated the relationship between the scalp distribution of fast (40-150 Hz) oscillations (FOs) and epileptogenic lesions in West syndrome (WS) and related disorders. Subjects were 9 pediatric patients with surgically confirmed structural epileptogenic pathology (age at initial electroencephalogram [EEG] recording: mean 7.1 months, range 1-22 months).

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Article Synopsis
  • - This study explores the use of bone marrow stromal cells (BMSCs) as a treatment for ischemic stroke and investigates whether electrical stimulation can effectively guide these cells to the damaged brain area in rats.
  • - Male Wistar rats underwent a right middle cerebral artery occlusion (MCAO) and received BMSCs injections combined with electrical stimulation, leading to improvements in behavioral outcomes and a reduction in stroke-induced brain damage compared to a control group.
  • - Results indicated that electrical stimulation not only enhanced the migration of BMSCs but also significantly improved neurological function and reduced infarction areas, highlighting its potential as a therapeutic strategy post-stroke.
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Objective: Optimal placement of electrodes is important for spinal cord stimulation. Factors affecting the difficulty of percutaneous electrode placement are not well known. In this study, we retrospectively evaluated the factors affecting the difficulty of percutaneous electrode placement.

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Article Synopsis
  • EEG data captures a wide range of brain activity, from very slow to high-frequency bands, with high-frequency oscillations (HFOs) being particularly important for understanding epilepsy.
  • HFOs, especially ripple and fast ripple oscillations, are linked closely to the potential for seizures and may serve as biomarkers for epileptogenicity, making their study critical for epilepsy treatment.
  • Advances in technology now allow for the noninvasive detection of fast oscillations (FOs) in the gamma and ripple bands, broadening research opportunities and implications for epilepsy monitoring and surgery.
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