Board members' nationality, corruption, and corporate climate change risk in UK firms: Evidence from OECD and Non-OECD board members.

Drawing on imprinting theory and upper echelons theory, this study examines how the countries of origin of board members influence their ethical orientations and governance behaviors related to environmental risk management. Specifically, we explore whether board members from non-OECD countries, where corruption is often more culturally tolerated, are associated with higher climate risk in firms compared to their OECD counterparts. Using a sample of 77 publicly traded UK companies listed on the FTSE 100 index across 11 industries from 2013 to 2022, our findings show that board corruption significantly increases climate change risk, particularly when directors are from non-OECD countries.

Unveiling the anti-diabetic effects of fruit pericarp and leaf radical scavenging, alpha-glucosidase inhibition, pharmacokinetics, and molecular docking of Q-TOF-LCMS identified compounds.

is traditionally used to treat diabetes in Malaysia. However, scientific studies have yet to identify the phytoconstituents responsible for its blood glucose-lowering effects. This study aimed to evaluate the antioxidant and α-glucosidase inhibitory effects of fruit pericarp and leaf dichloromethane (DCM) and ethanol (EtOH) extracts and identify the active principles.

Neurocardiology and neurodegenerative disease: Emerging research on emotional regulation and brain-heart connectivity.

This chapter explores the intricate relationship between neurocardiology and neurodegenerative diseases, shedding light on the complex interplay between the brain and heart. It delves into the nervous control of cardiac function, emphasizing the role of intrinsic and extrinsic neural networks. The text examines emotional regulation's impact on cardiovascular health, highlighting the neuroendocrine pathways involved in stress responses.

Review on 3D Printing Filaments Used in Fused Deposition Modeling Method for Dermatological Preparations.

Three-dimensional printing, particularly Fused Deposition Modeling (FDM), has revolutionized dermatological drug delivery by offering the ability to create personalized and precise drug formulations. This technology enables the design of customized drug delivery systems using a variety of polymers, such as Polylactic Acid (PLA), Polyvinyl Alcohol (PVA), Polyethylene Glycol (PEG), and Polycaprolactone (PCL), each with unique properties that enhance drug release, patient compliance, and treatment efficacy. This review analyzes these polymers in terms of their advantages, limitations, and suitability for dermatological applications.

Two walls versus three wall orbital decompression for thyroid eye disease: A systematic review and meta-analysis.

Objective: To assess whether three-wall surgical orbital decompression confers any benefit over two-wall surgical orbital decompression in terms of decrease in proptosis and new-onset diplopia.

Methods: The systematic review was conducted in 2020, and comprised literature search on Elton B. Stephens Co, Cumulative Index to Nursing and Allied Health Literature, Wiley Cochrane Library, Web of Science and PubMed databases for studies published from 1948 to 2019 that compared two-wall (medial and inferior) endoscopic decompressions with three-wall decompression.

Revolutionizing Medicine: Chatbots as Catalysts for Improved Diagnosis, Treatment, and Patient Support.

Chatbots have emerged as one of the revolutionary tools in healthcare that combine artificial intelligence to improve patient engagement in diagnosis, treatment, monitoring, and support. In this review, the application of chatbots in medicine over the past two decades is discussed, focusing on their application in several aspects of medicine, including oncology, psychiatry, and chronic disease management. A total of 38 clinically relevant studies were identified from a comprehensive literature search.

Development of sulfamoylbenzamide-based capsid assembly modulators for hepatitis B virus capsid assembly.

Hepatitis B virus (HBV) is a leading cause of chronic hepatitis and remains a significant global public health concern due to the lack of effective treatments. HBV replicates through reverse transcription within the viral capsid, making capsid assembly a promising antiviral target. However, no approved therapies currently target this process.

Enhanced Wound Healing with Phytosomal Gel: Extraction, Formulation, and Evaluation.

Background: This study explores the formulation and effectiveness of a phytosomal gel for enhancing wound healing.

Objective: The ethanolic extract of roots, rich in bioactive compounds like alkaloids and flavonoids, was optimized into a phytosomal complex to improve absorption and dermal retention.

Methods: Characterization through GC-MS revealed compounds, such as 2-Heptadecenal and Bicyclo[ 4.

Tracheomalacia in patients undergoing thyroid surgery-What is the true estimate: A systematic review and meta-analysis.

Objectives: Tracheomalacia is defined as the weakening of the tracheal rings secondary to long-standing compression or inherent structural weakness, leading to stridor and airway compromise. The common etiological factor of tracheomalacia includes compression of the tracheal framework due to a large multinodular goiter. There are various management techniques described in the literature to manage a patient with tracheomalacia including tracheostomy, tracheal stenting, and tracheopexy.

Racioethnic disparities in comorbidities and outcomes following head and neck oncologic surgery.

Objectives: Racial disparities persist despite attempts to establish an egalitarian framework for surgical care. This study aimed to investigate racioethnic disparities in comorbidities and outcomes following surgery for head and neck tumors.

Methods: This retrospective study included adult patients who underwent head and neck oncologic surgery between 2008 and 2020 from the National Surgical Quality Improvement Program.

Korth toxicity: Experimental findings and future prospects.

(Roxb.) Korth, locally known as kratom, is a traditional medicinal plant from Southeast Asia, with mitragynine as its principal alkaloid. Similar to other medicinal plants, kratom has side effects and toxicities, which have been documented in scientific studies and case reports.

Incidence, Risk Factors and Outcomes of Urinary Tract Infections among Patients Undergoing Thyroidectomy: Insights from the ACS-NSQIP.

 Urinary tract infections (UTIs) represent a rare postoperative complication following thyroidectomy.  This study aimed to assess the clinicodemographic factors associated with the development of UTIs and subsequent outcomes among patients undergoing thyroidectomy.  This retrospective study used the National Surgical Quality Improvement Program (NSQIP) database to analyze patients who underwent thyroidectomy from 2005 to 2019.

Reference Intervals for Venous Blood Gas in Healthy Adults: A One-Year Prospective Study.

Background Venous blood gas (VBG) investigation is a widespread option for arterial blood gas analysis because it is easier to draw and has a lower risk of complications during phlebotomy. This study aimed to establish reference intervals for the accurate analysis of VBG results as there is a lack of published data. Method Dr.

New α-glucosidase inhibitors and antioxidants in optimized Jack leaves extract identified by gC-MS-based metabolomics and molecular docking.

Our earlier research demonstrated α-glucosidase inhibitory (AGI) and antioxidant activities of the optimised extract of leaves. It was reported having numerous compounds, although it was unclear which compounds exhibit the bioactivities as well as their binding interaction to the enzyme. This study aimed to identify the compounds possessing AGI and antioxidant activities in the extract utilising GC-MS-based metabolomics, and to analyse the ligand-enzyme binding interactions molecular docking.

Common pediatric surgical conditions and associated health-seeking behaviors in Pakistan: An urban and rural comparative assessment.

Approximately five billion people do not have access to necessary surgical treatment globally and up to 85% of children in LMICs are affected with conditions requiring surgical care by the age of 15 years. It is crucial to identify common surgical conditions in children in Pakistan to inform healthcare professionals and policymakers for effective resource allocation. This representative cross-sectional household survey conducted on children aged 5-10 years assessed existing surgical diseases and healthcare-seeking behaviors in the two largest provinces (Sindh and Punjab) of Pakistan.

Using Quality by Design Tools to Study Gel Formulation from Leaves and Conducting its Molecular Docking, and ADMET Analyses.

Introduction: This research aims to create a gel formulation of Brassica juncea leaf extract and assess its anti-inflammatory properties using an study. The anti-inflammatory activity has been compared with Diclofenac molecules in PDB id: 4Z69. Further, the Absorption, Distribution, Metabolism, Excretion, and Toxicity analysis has been performed to ensure the therapeutic potential and safety of the drug development process.

Impact of Drain Placement on Postoperative Complications after Thyroidectomy for Substernal Goiter.

 Despite the evidence against drain placement after thyroidectomy, there is a lack of consensus on drain use in patients with substernal goiter.  To assess the factors that increase the likelihood of drain placement and its impact on postoperative hematoma and other 30-day complications among adult patients undergoing thyroidectomy for substernal goiter.  A retrospective cohort study that used data from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP).

MEMO1 binds iron and modulates iron homeostasis in cancer cells.

Mediator of ERBB2-driven cell motility 1 (MEMO1) is an evolutionary conserved protein implicated in many biological processes; however, its primary molecular function remains unknown. Importantly, MEMO1 is overexpressed in many types of cancer and was shown to modulate breast cancer metastasis through altered cell motility. To better understand the function of MEMO1 in cancer cells, we analyzed genetic interactions of MEMO1 using gene essentiality data from 1028 cancer cell lines and found multiple iron-related genes exhibiting genetic relationships with MEMO1.

Sepsis and Septic Shock in Patients Undergoing Thyroidectomy: Incidence, Risk Factors, and Outcomes.

Introduction: Postoperative sepsis represents a rare complication following thyroidectomy. We aimed to explore the incidence, risk factors, sources, and outcomes of postoperative sepsis and septic shock among adult patients undergoing thyroidectomy.

Methods: Data from the American College of Surgeons National Surgical Quality Improvement Program were used in this retrospective cohort study.

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Seed Extract and Assessment of Its Anti-hemorrhoidal Efficacy.

Background: Seeds of plant are traditionally used by the healers of "India" for the treatment of piles.

Objectives: The primary objective of the study was to assess the anti-hemorrhoidal potential of the ethanolic seed extract of .

Methods: After the soxhlet extraction method, the seed extract from was first submitted to phytochemical standardization and then GC-MS analysis.

Oral health related quality of life in head and neck cancer survivors within the first year following treatment: a cross-sectional study in Karachi, Pakistan.

After completing treatment for head and neck cancer (HNC), patients often face oral complications like oral pain, limited mouth opening and dry mouth which significantly reduce their oral health related quality of life (OHRQoL). These issues impact their overall well-being, social activities and long-term survival. The primary objective of this study was to evaluate OHRQoL and its association with sociodemographic characteristics, oral hygiene practices and oral clinical parameters such as oral hygiene status and oral mucositis grade in patients who have completed treatment for head and neck cancer.

Recent Advances in the Development of Sulfamoyl-Based Hepatitis B Virus Nucleocapsid Assembly Modulators.

Hepatitis B virus (HBV) is the primary contributor to severe liver ailments, encompassing conditions such as cirrhosis and hepatocellular carcinoma. Globally, 257 million people are affected by HBV annually and 887,000 deaths are attributed to it, representing a substantial health burden. Regrettably, none of the existing therapies for chronic hepatitis B (CHB) have achieved satisfactory clinical cure rates.

The Acute Effects of the Use of Salbutamol and Ipratropium on the Heart Rates of Patients With Obstructive Airway Disease.

Background The cornerstone of pharmaceutical therapy for obstructive airway illnesses involves inhalation of bronchodilators, such as ipratropium bromide (IP) and salbutamol (SB). The heart rate regulation may be changed by β-2 agonists and anticholinergic medications. Investigating the impact of inhaled SB and IP on the heart rate was the goal of this study.