Publications by authors named "Susan Roustaee"
Pain relievers such as tramadol are among the most commonly prescribed around the world. However, Long-term tramadol use has been shown to cause neurotoxicity, neuroinflammation, and cognitive impairment, which has limited its clinical use. Elderberry (EB), a plant extract widely recognized for its medicinal properties, is used in this study to investigate the effects of a plant-based diet on tramadol's adverse effects in the hippocampus region.
View Article and Find Full Text PDFBromelain is a plant-based molecule with antioxidant, antithrombotic, anticancer, and anti-inflammatory properties. Bromelain has been shown to reduce the release of inflammatory cytokines. This study aimed to determine whether bromelain can prevent ataxia in rats caused by 3-acetylpyridine (3-AP).
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- * LDX-treated rats showed impaired memory performance in various tests and exhibited changes in brain activity, with an increase in field excitatory postsynaptic potential and elevated caspase-3 levels, indicating potential cell death.
- * The study found significant increases in immune cells (microglia and astrocytes) in the hippocampus, along with changes in cell structure, pointing to harmful effects of LDX on this vital area of the brain related to memory; more research is required to fully understand
Article Synopsis
- Concerns about lisdexamfetamine (LDX), a drug for ADHD, include potential irreversible brain damage and impacts on the neuroendocrine system during development.
- A study on adult male rats found that LDX treatment resulted in decreased sperm motility, increased DNA fragmentation, and significantly lower testosterone levels.
- The study suggests prolonged LDX use may lead to poor sperm quality and harmful changes in testicular tissue, but further research is needed, especially in humans using LDX long-term.